4-(2′,4′-二氟苯基)苯乙酮的合成研究  

STUDY ON SYNTHESIS OF 4-(2', 4'-DIFLUOROPHENYL) ACETOPHENONE

作　　者：周卫红[1] 楼其向[1] 许文松[1] 

机构地区：[1]浙江大学材料与化工学院,杭州310027

出　　处：《精细石油化工》2004年第4期21-24,共4页Speciality Petrochemicals

摘　　要：以2’,4’-二氟联苯为原料,以乙酰氯为酰化剂,二氯甲烷为溶剂,经Friedel-Crafts酰化反应制备了4-(2’,4’-二氟苯基)苯乙酮,确定的最佳反应条件为:乙酰氯的添加温度低于15℃,反应温度25℃,二氟联苯/乙酰氯/三氯化铝(摩尔比)为1:1.22:1.34,反应时间为3 h,并对后处理过程进行了改进,4-(2’,4’-二氟苯基)苯乙酮的最佳收率达到96.3％(基于二氟联苯),熔点70～72℃,纯度98.5％。Using acetyl chloride as acetylating agent and dichloromethane as solvent, the 4-(2',4'-difluorophenyl) acetophenone was synthesized from 2', 4'-difluorobiphenyl via Friedel-Crafts reaction. The optimal synthetic conditions were obtained as follows: n(2',4'-difluorobiphenyl): n(acetyl chloride): n(AlCl_3)=1:1.22:1.34, addition temperature of ace tyl chloride<15℃, reaction temperature 25℃, reaction time 3h, and the after treatment of the product was improved also. The molar yield of product is over 96%(based on 2',4'-difluorobiphenyl), m.p. 70-72℃, purity 98.5%.

关 键 词：二氟苯基 苯乙酮 Friedel-Crafts酰化反应 合成研究 二氟联苯 最佳反应条件 乙酰氯 二氯甲烷 反应温度 三氯化铝 反应时间 处理过程 酰化剂 摩尔比 溶剂 收率 

分 类 号：TQ463.4[化学工程—制药化工] O625.42[理学—有机化学]