汞矿地区大米对大鼠生长发育及氧化损伤的影响  

Oxidative Damage in the Tissues of Rats Induced by Rice Harvested in Mercury Mining Area

作　　者：金桂文[1] 冀秀玲[1] 卢静[1] 杨义晨[1] 程金平[1] 王文华[1] 

机构地区：[1]上海交通大学环境科学与工程学院,上海200240

出　　处：《环境与健康杂志》2005年第3期180-182,共3页Journal of Environment and Health

基　　金：中国科学院知识创新工程重要方向项目(KZCX3-SW-437);国家自然科学基金资助项目(20177013)

摘　　要：目的探讨汞矿地区大米暴露对大鼠生长发育的影响及氧化损伤机制。方法利用汞矿地区大米及对照组大米分别对SD大鼠进行90d暴露实验,观察大鼠的体重变化情况,90d后处死,测定大鼠脑、肝、肾组织谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活力及还原型谷胱甘肽(GSH)、丙二醛(MDA)含量。结果与对照组相比,实验组大鼠的体重增幅较大,脑、肝、肾组织中GSH-Px、SOD活力和GSH含量降低(P<0.05),MDA含量升高,差异均有统计学意义(P<0.01)。结论大鼠暴露于汞污染大米90d后脑、肝、肾均产生了明显的脂质过氧化。Objective To study the growth and oxidative damage of rats exposed to mercury mining area rice. Methods The rats were exposed to the rice harvested in mercury mining area or in other area for 90 days, and then determined the change of their weight, the activity of SOD and GSH-Px, the content of MDA and GSH in brain, liver and kidney tissue. Results After 90 days of exposure, compared with the control,significantly higher weight,higher level of MDA,lower activities of GSH-Px,SOD and lower level of GSH were found in brain, liver and kidney tissue of the rat of exposure group. Conclusion The results of the present paper show that the rice contaminated by mercury in this mercury mining area may induce lipid peroxidation in the rat's in brain, liver and kidney tissue.

关 键 词：汞 大米 大鼠 脂质过氧化 

分 类 号：R994.6[医药卫生—毒理学]