慢性乙肝硬化B超图像与胆汁酸、前白蛋白、胆碱酯酶临床价值的研究  

B mode ultrasound and serum TBA,PAB and CHE levels in evaluating liver cirrhosis with hepatitis B

作　　者：孙洪军[1] 赵继梅[1] 范卫华[1] 

机构地区：[1]山东省立医院,山东济南250021

出　　处：《医疗设备信息》2005年第4期64-65,共2页Information of Medical Equipment

摘　　要：目的明确慢性乙肝肝硬化B超分级与肝功指标:胆汁酸(TBA)、前白蛋白(PAB)、胆碱酯酶(CHE)判断肝纤维化分期的价值。方法检测78例经肝活检证实的慢性乙肝肝硬化患者声像图改变与TBA、PAB及CHE水平,并与肝活检组织纤维化分期进行对照研究。结果肝脏病理组织纤维化分为S1 -S4期78例。中代偿期(S1 -S2)38例,失代偿期(S3 -S4)40例。B超诊断符合率,代偿期90.6 %,失代偿期为97.3 %。随着纤维化程度的加重,PAB、CHE逐渐下降,TBA逐渐升高。TBA、CHE与纤维化分期存在良好的相关性(P<0.01) ,PAB与纤维化分期存在较弱的相关性(P<0.05)。结论肝脏B超的声像图改变与TBA、PAB、CHE指标在一定程度上可以提示早期肝硬化。Objective According to the change of B ultrasound and serum TBA,PAB,CHE levels to evaluate the grades liver cirrhosis in patients with chronic hepatitis B.Methods Detecting the serum TBA,PAB,CHE levels of78chronic hepatitis B patients determined by liver histopatholgical findings and making.B ultrasonic examination and comparing the results with the grades of fibrosis.Results The grade of liver fibrosis is from S1to S4,38patients was in compensation stage(S1-S2)and40patients was out of compensation(S3-S4).The coincide of the ultrasound and the liver fibrosis was90.6%in compensation,97.3%out of compensation.PAB and CHE declined and TBA rose gradually with the aggravation of fibrosis.The correlation between TBA.CHE and fibrosis in significant(P<0.01).The correlation between PAB and fibrosis in significam(P<0.05).Conclusion B mode ultrasound and serum TBA,PAB,CHE has their own benefit in eˉvaluating early liver cirrhosis.

关 键 词：肝硬化 B超 胆汁酸 前白蛋白 胆碱酯酶 

分 类 号：R575.2[医药卫生—消化系统]