Ototoxicity of a new glycopeptide, norvancomycin with multiple intravenous administrations in guinea pigs  

作　　者：GaoW ZhangS LiuH ZhangY DiaoM HanH DuL 

机构地区：[1]DepartmentofPhysiology,LaboratoryofOto-toxicology,SecondMilitaryMedicalUniversity,Shanghai200433,China

出　　处：《第二军医大学学报》2005年第5期534-534,共1页Academic Journal of Second Military Medical University

摘　　要：Time courses of plasma concentration of a new glycopeptide, norvancomycin (NVCM) after single intravenous (iv) and intraperitoneal (ip) injection, and the peak plasma concentrations (Cmax's) of this drug at various doses after single iv injection were determined in guinea pigs. There were significant differences in pharmaeokinetic parameters between the two routes of administration and the Cmax linearly increased with the dose used increasing. Guinea pigs with normal hearing were then used to investigate ototoxic liability of NVCM after multiple intravenous administrations (54, 108, 216 mg/kg, qd for 14 days).

分 类 号：R[医药卫生]