p53 CD44V6及nm23/NDPK在非小细胞肺癌中表达的相关性分析  

Relationship between Expression of p53, CD44V6 and nm23/NDPK in Non-small Cell Lung Cancer

作　　者：纪远中[1] 聂卫[1] 张志尧[2] 戈以椿[2] 匡朴[1] 李德华[1] 王士贤[1] 

机构地区：[1]天津市医药科学研究所,天津市300020 [2]天津市胸科医院

出　　处：《中国肿瘤临床》2005年第10期561-563,共3页Chinese Journal of Clinical Oncology

基　　金：天津市卫生局科技基金资助(编号:021103004)

摘　　要：目的:探讨非小细胞肺癌(NSCLC)中p53、CD44V6及nm23/NDPK表达的相关性及预后意义。方法:采用免疫组织化学SP法对69例NSCLC组织中p53、CD44V6及nm23/NDPK进行检测。结果:p53、CD44V6及nm23/NDPK的表达与NSCLC患者的临床分期(P<0.05,P<0.01)、淋巴结转移(P<0.05,P<0.01)及生存率(P<0.05)密切相关。p53、CD44V6表达与nm23/NDPK在NSCLC中的表达呈明显负相关(P<0.01)。结论:联合检测NSCLC中p53、CD44V6及nm23/NDPK的表达对于判断预后和指导治疗可能具有实用价值。Objective: This study was designed to investigate the expression of p53,nm23/NDPK and CD44V6 and their correlations in non-small cell lung cancer (NSCLC). Methods: The expression of p53, CD44V6 and nm23/NDPK was immunohistchemically detected using SP methods in 69 cases with NSCLC. Results: The expression of p53, CD44V6 and nm23/NDPK was significantly related with the staging of the disease (P<0.05, P<0.01), the lymph node involvement ratio (P<0.05, P<0.01) and postoperative survival (P<0.05). Conclusion: Combined detection on the expression of p53, CD44V6 and nm23/NDPK in NSCLC may has the practical value in prognosis of the patients.

关 键 词：非小细胞肺癌p53 CD44V6 NM23/NDPK 预后 

分 类 号：R734.2[医药卫生—肿瘤]