9例低度恶性肌纤维母细胞肉瘤的临床病理观察  

Low-grade Myofibrosarcoma: A Clinicopathologic Study

作　　者：仇晓菲[1] 孙保存[2] 张立华[2] 吕志军[1] 朱晓光[1] 林建韶[1] 

机构地区：[1]天津医科大学病理教研室 [2]天津市肿瘤医院肿瘤研究所病理室,天津市300060

出　　处：《中国肿瘤临床》2005年第10期582-584,591,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨低度恶性肌纤维母细胞肉瘤(LGMS)的临床病理特征及其治疗。方法:分析9例LGMS的临床和病理特征,并进行免疫组化标记。结果:9例均行手术切除,其中3例第一次手术为广泛切除术。本病肿瘤细胞特点为胞浆嗜酸而核两端尖,弥漫性广泛表达SMA和MSA。7例获随访资料,2例分别于术后5个月和7年复发,后者半年后2次复发并转移至舌。结论:LGMS是光镜下可辨认的低度恶性肉瘤,其临床重要性在于与假肉瘤性病变鉴别,手术切除干净并密切随访以避免复发。Objective: To study the clinicopathologic features and treatments of low-grade myofibrosarcoma (LGMS). Methods: The clinical and pathologic features of 9 cases with LGMS were analyzed using immunohistochemistry. Results: All patients were treated surgically, among which three of them were initially treated by wide excision. The tumor cells, with eosinophilic cytoplasm and tapered nuclei, were diffusely strong positive for SMA and MSA. Follow-up in 7 patients (median:) revealed recurrence in two cases 5 months and 7 years after local excision, and further recurrence and tongue metastases in the latter one 6 months after the re-excition. Conclusion: It has been confirmed in this research that LGMS is a low-grade malignant tumor, which can be recognized at light microscopy. The clinical significance is to avoide confusion with psuedosarcomatous conditions. Complete surgical resection and close follow-up are both necessary in the treatment to avoid recurrences.

关 键 词：低度恶性肌纤维母细胞肉瘤 免疫组化 诊断 

分 类 号：R730.4[医药卫生—肿瘤]