Comparative Study of Apoptosis-related Gene Loci in Human,Mouse and Rat Genomes  

作　　者：Yan-BinYIN YongZHANG PengYU Jing-ChuLUO YingJIANG Song-GangLI 

机构地区：[1]CenterofBioinformatics,NationalLaboratoryofGeneticEngineeringandProteinEngineering,CollegeofLifeSciences,PekingUniversity,Beijing100871,China

出　　处：《Acta Biochimica et Biophysica Sinica》2005年第5期341-348,共8页生物化学与生物物理学报（英文版）

基　　金：This work was supported by a grant from the National High Technology Research and Development Program of China(No.2002AA231051)

摘　　要：Many genes are involved in mammalian cell apoptosis pathway.These apoptosis genes often contain characteristic functional domains,and can be classified into at least 15 functional groups,according to previous reports.Using an integrated bioinformatics platform for motif or domain search from three public mammalian proteomes(International Protein Index database for human,mouse,and rat),we system- atically cataloged all of the proteins involved in mammalian apoptosis pathway.By localizing those proteins onto the genomes,we obtained a gene locus centric apoptosis gene catalog for human,mouse and rat. Further phylogenetic analysis showed that most of the apoptosis related gene loci are conserved among these three mammals.Interestingly,about one-third of apoptosis gene loci form gene clusters on mammal chromosomes,and exist in the three species,which indicated that mammalian apoptosis gene orders are also conserved.In addition,some tandem duplicated gene loci were revealed by comparing gene loci clusters in the three species.All data produced in this work were stored in a relational database and may be viewed at http://pcas.cbi.pku.edu.cn/database/apd.php.Many genes are involved in mammalian cell apoptosis pathway.These apoptosis genes often contain characteristic functional domains,and can be classified into at least 15 functional groups,according to previous reports.Using an integrated bioinformatics platform for motif or domain search from three public mammalian proteomes(International Protein Index database for human,mouse,and rat),we system- atically cataloged all of the proteins involved in mammalian apoptosis pathway.By localizing those proteins onto the genomes,we obtained a gene locus centric apoptosis gene catalog for human,mouse and rat. Further phylogenetic analysis showed that most of the apoptosis related gene loci are conserved among these three mammals.Interestingly,about one-third of apoptosis gene loci form gene clusters on mammal chromosomes,and exist in the three species,which indicated that mammalian apoptosis gene orders are also conserved.In addition,some tandem duplicated gene loci were revealed by comparing gene loci clusters in the three species.All data produced in this work were stored in a relational database and may be viewed at http://pcas.cbi.pku.edu.cn/database/apd.php.

关 键 词：APOPTOSIS gene cluster comparative genomics BIOINFORMATICS 

分 类 号：Q343[生物学—遗传学] Q255