脑缺血耐受与细胞凋亡的调控  

Cerebral ischemic tolerance and the regulation of apoptosis

作　　者：王岩[1] 陈立杰[1] 

机构地区：[1]哈尔滨医科大学附属第二医院神经科,黑龙江省哈尔滨市150086

出　　处：《中国临床康复》2005年第17期168-169,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:在探讨脑缺血后内源性神经保护机制、开发新的神经保护药物或方法的过程中,脑缺血耐受的形成机制的基础研究是非常必要的。现就脑缺血耐受的形成与细胞凋亡调控的相关基础研究进行综述。资料来源:应用计算机检索Medline1980-01/2004-01关于脑缺血耐受和细胞凋亡的文章,检索词“cerebralischemictolerance,cellapopto-sis”,并限定语言种类为English。同时计算机检索万方数据资源系统与中国期刊全文数据库1990-01/2004-01关于脑缺血耐受和细胞凋亡的文章,限定文章语言种类为中文,检索词“脑缺血耐受,细胞凋亡”。资料选择:对资料进行初审,纳入标准为①随机对照实验,采用单盲,双盲或非盲法。②实验包含平行对照组。③无其他施加因素。排除标准:重复性实验研究和综述。选取实验包括实验组和对照组的文献,筛除非随机实验的研究,对符合标准的文献开始查找全文,进一步判断为随机对照实验。资料提炼:共收集到20篇关于脑缺血耐受形成与细胞凋亡的相关研究的随机和未随机实验文章,14个实验纳入标准,因重复的同一研究或类似研究排除的6篇实验。资料综合:14个实验包括bcl-2,bax,p53,蛋白激酶B,低浓度的神经酰胺,半胱氨酸天冬氨酸蛋白酶3和细胞色素C对脑缺血耐受的影响并对其给予评价。OBJECTIVE:The basic study on formation of cerebral ischemic tolerance is necessary during the period of investigating endogenetic neural protective mechanism after cerebral ischemia and developing neural protective drugs or methods,so we summarize the relevant clinical study of the formation of cerebral ischemic tolerance and the regulation of apoptosis in this paper.DATA SOURCES:Using the key terms “ cerebral ischemic tolerance,cell apoptosis',we searched the MEDLINE database for the relevant articles about cerebral ischemic tolerance and apoptosis published in English from January 1980 to January 2004.Meanwhile,using the same key terms in Chinese, we searched the Wanfang database and Chinese journals full text database from January 1990 to January 2004.STUDY SELECTION:All articles were selected firstly.The inclusive criteria included① randomized controlled trials,single blind,double blind or non blind;② the trails contained control group;③ other factors did not exist.The duplicated studies and summarizations were excluded.Articles containing experimental and control groups were collected.The non randomized trials were excluded and the rest full text was looked up to judge whether they were randomized controlled trials or not.DATA EXTRACTION:A total of 20 articles of randomized and non randomized trials were collected,which were relevant to formation of cerebral ischemic tolerance and apoptosis.Fourteen among them met the inclusive criteria, and 6 were excluded because of duplicated same or similar studies.DATA SYNTHESIS:Fourteen trails studied the effect of bcl 2,bax,p53,Akt,ceramide with lower concentration,Caspase 3 and cytochrome C on cerebral ischemic tolerance,meanwhile which were evaluated.CONCLUSION:Now,no sufficiently evidence can prove the clinical applied value of cerebral ischemic tolerance.But cerebral ischemic tolerance is still the powerful method to investigate the endogenetic neural protective mechanism after cerebral ischemia and develop new neural protective drugs.

关 键 词：细胞凋亡 脑缺血 综述文献 

分 类 号：R743[医药卫生—神经病学与精神病学]