骶神经根对膀胱功能的选择性支配(英文)  

Selective innervation of sacral nerve roots to bladder

作　　者：王金武[1] 侯春林[2] 卢宁[3] 王诗波[2] 王永胜[2] 曹银祥[3] 

机构地区：[1]上海交通大学附属上海市第六人民医院骨科,上海市200233 [2]上海第二军医大学附属长征医院骨科,上海市200003 [3]复旦大学基础医学院生理学教研室,上海市200032

出　　处：《中国临床康复》2005年第17期227-229,共3页Chinese Journal of Clinical Rehabilitation

基　　金：国家自然科学基金(30170956);上海市博士后科研基金(01-1)~~

摘　　要：背景:SD大鼠不同骶神经根对膀胱功能的选择性支配作用目前仍不十分清楚。目的:研究骶神经根对膀胱功能的选择性支配,为临床脊髓损伤后的膀胱功能重建及建立实验性人工膀胱动物模型提供依据。设计:随机对照实验。单位:两所大学的骨科,一所大学医学院的生理学教研室。材料:2000-10/2002-06在复旦大学医学院卫生部手功能重建重点实验室进行实验,雄性清洁级SD大鼠10只,体质量250～300g。干预:随机分为2组,其中一组左侧为实验侧,另一组右侧为实验侧。对10只脊髓损伤后的SD大鼠进行硬膜外S1～4神经根电刺激。主要观察指标:记录膀胱神经丛动作电位和膀胱平滑肌复合肌肉动作电位变化,同时通过膀胱内插入测压管并经压力换能器记录膀胱内压的变化。结果:S1～4神经均参与SD大鼠的膀胱神经功能支配,其中以S2神经最主要,S1,S3神经次之,S4神经的支配作用最小。结论:不同的骶神经根对膀胱平滑肌的支配效能不同,利用膀胱平滑肌的主要支配神经根进行人工电刺激排尿或通过神经吻合重建人工膀胱反射弧,对提高脊髓损伤患者的膀胱排尿功能有一定的意义。BACKGROUND:The selective innervation of different sacral nerve roots on bladder in SD mice is still uncertain.OBJECTIVE:To study the selective innervation of sacral nerve roots to bladder in order to provide evidence for rebuilding bladder function after spinal cord injury and establishing experimental animal model of artificial bladder.DESIGN:Randomized and controlled study. SETTING:Department of orthopaedics in two universities and physiological department of a medical university.MATERIALS:The experiment was conducted in the Key Laboratory of Hand Function Reconstruction of Ministry of Public Health in Medical College of Fudan University from October 2000 to June 2002.Totally 10 male SD mice of clean class with body mass between 250 and 300 g were chosen. INTERVENTIONS:The mice were randomly divided into two groups of which one used left side as experimental side and the other used right side.Extradural electric stimulation was conducted to S1- 4 nerve roots of SD mice after spinal cord injury.MAIN OUTCOME MEASURES:To record the change of action potential of cystic nerve plexus and compound muscle action potential of bladder smooth muscle,and insert the pressure monitor into bladder to record internal pressure of bladder by pressure transducer. RESULTS:S1- 4 nerve all participate the innervation of bladder in SD mice, among them, the S2 nerve is the most important one, next with S1, S3 and S4 is the minimum one.CONCLUSION:Different sacral nerve roots have different dominative effects to bladder smooth muscle.It is meaningful for patients of spinal cord injury to improve their urination function by performing artificially electric stimulation for emiction through the main nerve roots controlling of bladder or rebuilding artificial bladder reflex arc by neurorrhaphy

关 键 词：电刺激 膀胱 去神经支配 

分 类 号：R743[医药卫生—神经病学与精神病学]