干细胞移植:神经系统疾病治疗的新策略(英文)  

Stem cell transplantation:a new strategy for treatment of nervous system diseases

作　　者：王春雪[1] 王拥军[1] 万虹[2] 毛淑静[3] 历俊华[2] 刘丽萍[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经内科,北京市100050 [2]北京市神经外科研究所,北京市100050 [3]河北医科大学2002级,研究生河北省石家庄市050017

出　　处：《中国临床康复》2005年第17期254-256,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:干细胞特别是神经干细胞移植治疗神经系统疾病在动物实验中已得到了证实,这为临床神经系统疾病的治疗尤其是其功能的恢复带来了新的希望。近年来有关干细胞及神经干细胞在神经系统疾病研究中的成果较多,从不同的效果及其机制方面提出了干细胞及神经干细胞在神经系统再生修复过程中的假说理论并进行了相关的临床验证。资料来源:应用计算机检索Medline数据库1997-01/2003-08期间的文章,检索词为stemcell,neuralstemcell,bonemarrowstromalcell,stroke,ischemicinjury,nervoussystemdisease,neurotrophicfactor”分别组合进行检索,限定文章语言种类为英文。同时检索万方数据库2003-01/2004-12期间的相关文章,检索词干细胞,神经干细胞,骨髓基质细胞,卒中,缺血性脑损伤,神经营养因子,限定文章语言种类为中文。资料选择:对资料进行初筛,选出与研究关系密切的文献。纳入标准:研究对象为动物或人,包括干细胞及神经干细胞的基础与临床研究内容。重点选取与缺血性神经损伤相关的文献。资料提炼:共收集到文献72篇,其中与本研究关系密切的文献14篇,间接相关的文献10篇,排除重复性文献8篇,共16篇文献用于资料的综述。资料综合:对于选取的文献进行阅读、归纳和综合。结果显示神经干细胞在脑血管病、脑和脊髓损伤?OBJECTIVE:Transplantation of stem cell,especially neural stem cell,has been proven effective in treating nervous system diseases in animal models,which provides new hopes for recovery of nerve functions in patients suffering from various nervous system diseases.Multiple studies have been conducted on the role of neural stem cells in repairing nerve functions,and several hypotheses have been proposed to explain how the stem cells or neural stem cells acts to recover nerve function.DATA SOURCES:We searched Medline for English articles from January 1997 to August 2003 with stem cell,neural stem cell,bone marrow stromal cell,stroke,ischemic injury,nervous system disease,and neurotrophic factor as the keywords.We also searched Wangfang database for Chinese articles with the same keywords from January 2003 to December 2004.STUDY SELECTION:The articles found in these two databases were primarily screened with the inclusion criteria as follow:the subjects should be animals or human;and the study should be the basic and/or clinical researches on(neural) stem cells.DATA EXTRACTION:Totally 72 English and Chinese articles were found in the two databases,among which 14 articles were closely associated with the present study and 10 were indirectly related.Eight articles were excluded for repetition in the contents.Finally 16 articles were included for analysis.DATA SYNTHESIS:The full text of the articles were reviewed and summarized.The results of these articles suggest that neural stem cells are valuable in treating cerebral vascular diseases,brain and spine injury,nerve degeneration diseases,and peripheral nerves diseases.CONCLUSION:Stem cells,especially neural stem cells,play active roles in treating nervous systeme diseases such as differentiation promotion,nerves nourishing,and nerve substitute.

关 键 词：干细胞移植 骨髓细胞 神经系统疾病 

分 类 号：R74[医药卫生—神经病学与精神病学]