Research progress on Helicobacter pyloriouter membrane protein  

作　　者：Shi-HeShao HuaWang Shun-GenChai Li-MeiLiu 

机构地区：[1]DepartmentofMedicalMicrobiologyandParasitology,MedicalTechnologyCollege,JiangsuUniversity,Zhenjiang212001,JiangsuProvince,China [2]GraduateStudent,MedicalCollege,NorthernUniversity,Jilin13201,JilinProvince,China

出　　处：《World Journal of Gastroenterology》2005年第20期3011-3013,共3页世界胃肠病学杂志（英文版）

基　　金：Supported by the Research Plan of Jiangsu Provincial Technology Commission, No. BS2004021Advanced Talent Research Plan of Jiangsu University, No. JDG2004008

摘　　要：Helicobacter pylori (H pylori), one of the most common bacterial pathogens on human beings, colonizes the gastric mucosa. In its 95 paralogous gene families, there is a large outer membrane protein (OMP) family. It includes 32 members. These OMP are important for the diagnosis, protective immunity, pathogenicity of H pylori and so on. They are significantly associated with high H pylori density,the damage of gastric mucosa, high mucosal IL-8 levels and severe neutrophil infiltration. We introduce their research progress on pathogenicity.Helicobacter pylori (H pylori), one of the most common bacterial pathogens on human beings, colonizes the gastric mucosa. In its 95 paralogous gene families, there is a large outer membrane protein (OMP) family. It includes 32 members. These OMP are important for the diagnosis, protective immunity, pathogenicity of H pylori and so on. They are significantly associated with high H pylori density, the damage of gastric mucosa, high mucosal IL-8 levels and severe neutrophil infiltration. We introduce their research progress on pathogenicity.

关 键 词：H pylori Outer membrane protein OIPA Gastric carcinoma 

分 类 号：R573[医药卫生—消化系统] R378.99[医药卫生—内科学]