运动锻炼防治绝经后骨质丢失的临床研究  

A clinical study of exercise training on postmenopausal osteoporosis

作　　者：谢晶[1] 沈霖[1] 杨艳萍[1] 周丕琪[1] 高兰[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院中医科,武汉430022

出　　处：《中国康复医学杂志》2005年第3期191-192,199,共3页Chinese Journal of Rehabilitation Medicine

摘　　要：目的:研究慢跑、跳舞等运动锻炼防治绝经后骨质丢失的作用和机制。方法:45例绝经后女性随机分为运动组和对照组。运动组患者每天锻练40—50min,同时每天补充钙;对照组仅每天补充元素钙600mg,为期1年。研究开始和结束时检测受试者腰椎和股骨上端骨密度,以及血清骨钙素(s-BGP)和尿羟脯氨酸与肌酐(Hyp/Cr)。结果:1年后,运动组腰椎骨密度显著上升(P<0.05),而其股骨颈、Ward's三角区和股骨粗隆处骨密度无显著变化(P>0.05),对照组各处骨密度均明显下降(P<0.05)。运动组s-BGP和Hyp/Cr比值无变化,而对照组则显著上升(P<0.05)。结论:慢跑、跳舞等运动锻炼可通过抑制骨转换而防治绝经后骨质丢失。Objective:To study the effect of exercise training on bone loss in postmenopausal women and its possible mechanism.Method:Forty-five postmenopausal women were randomly divided into exercise group who exercise 40-50min per day and the control group treated with calcium preparation alone.The course for both group was 1 year.Bone mineral density(BMD) of lumbar vertebra and upperfemur,serum osteocalcin(s-BGP) and urinary oxyproline hydroxyproline/creatinine ratio(Hyp/Cr) were determined at the beginning and ending of the study.Result: After 1 year exercise training,the BMD of lumbar vertebra increased significantly(P<0.05), while BMD of femoral neck,Ward's triangular space and femoral trochanter remained unchanged(P>0.05).But the BMD in different parts in the control group were all decreased significantly.Moreover,s-BGP and Hyp/Cr ratio are all raised in the control group but unchanged in the exercise group.Conclusion:Exercise training can prevent and treat postmenopausal bone loss through inhibiting bone turn-over.

关 键 词：骨质丢失 运动锻炼 临床研究 防治 绝经后女性 尿羟脯氨酸 血清骨钙素 腰椎骨密度 对照组 运动组 股骨上端 股骨粗隆 补充钙 受试者 1年后 股骨颈 三角区 Hyp BGP 骨转换 慢跑 跳舞 上升 

分 类 号：R455[医药卫生—运动医学]