结肠嗜酸细胞癌2例临床病理分析  

Clinicopathological features of oncocytic carcinoma of colon

作　　者：李刚强[1] 曹金龙[1] 王丽霞[1] 

机构地区：[1]解放军455医院病理科,上海200052

出　　处：《临床与实验病理学杂志》2005年第2期176-178,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的　探讨结肠嗜酸细胞癌的病理组织学特点、诊断及鉴别诊断。方法　对2例结肠嗜酸细胞癌手术切除标本进行光镜、免疫组化染色及电镜观察。结果　结肠嗜酸细胞癌组织学特点为细胞圆形、多边形,胞质丰富,胞质内见弥漫分布的强嗜酸性颗粒,细胞核中度异型性,核仁明显;癌细胞呈巢状排列,伴有腺管及乳头形成。免疫表型:癌细胞CK19、EMA阳性表达,不表达SMA、S- 100蛋白及CgA。PAS染色阴性。电镜观察细胞质充满大量线粒体,缺乏内分泌及外分泌颗粒。结论　嗜酸细胞癌是不同于低分化腺癌及神经内分泌癌的一种特殊类型细胞癌。Purpose To study the histopathological characteristics of oncocytic carcinoma of the colon and its differential diagnosis. Methods Two case of primary oncocytic carcinoma of the colon were studied by light microscopy,immunohistochemistry and electron microscopy. Results The lesion was constituted by the proliferation of round to polygonal cells which had 'low-grade' nuclei and abundant cytoplasm with deeply eosinophilic granules dispersing widely throughout it. Immunohistochemical staining showed strong positive expression of CK19 and EMA in the tumor cells,and no expression of smooth muscle actin,S-100 protein and chromogranin A. Ultrastructural features were numerous mitochondrion in tumor cells. No secretory granules were observed in tumor cells. Conclusion Colonic oncocytic carcinoma is a distinct variant which is different from poor adenocarcinoma and neuroendocrine carcinoma.

关 键 词：结肠肿瘤 嗜酸细胞癌 免疫组织化学 超微结构 

分 类 号：R735.35[医药卫生—肿瘤]