新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物的合成及抗菌活性  

Synthesis and Antibacterial Activities of Novel 4-Substituted-6-(4-chlorophenyl)-7-(1H-1,2,4-triazol-1-yl)-1',2',4'-triazolo[3,4-b]-1",3",4"-thiadiazines

作　　者：惠新平[1] 张艳[1] 许鹏飞[1] 王勤[2] 张琪[2] 张自义[1] 

机构地区：[1]兰州大学功能有机分子化学国家重点实验室化学化工学院,兰州730000 [2]兰州大学生命科学学院,兰州730000

出　　处：《有机化学》2005年第6期700-704,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20021001)资助项目.

摘　　要：通过3-取代-4-氨基-5-巯基-1,2,4-三唑(3a～3m)和2-溴-2-(1H–1,2,4-三唑-1-基)-4′-氯代苯乙酮(2)的缩合反应,合成了13个新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物4a～4m.化合物结构经元素分析,1HNMR,IR和MS进行了表征.抗菌试验表明所合成的化合物对细菌表现出中等程度的抑制活性.The synthesis of novel 4-substituted-6-(4-chlorophenyl)-7-(1H-1,2,4-triazol-1-yl)-s-triazolo[3,4- b]-1',3',4'-thiadiazines (4a～4m) by the condensation of 4-amino-5-mercapto-3-substituted-1,2,4-triazoles (3a～3m) with 2-bromo-2-(1H-1,2,4-triazol-1-yl)-4′-chloroacetophenone (2) was described. The structures of compounds were confirmed by elemental analyses, IR, 1H NMR and mass spectral data. These com- pounds have also been screened for their antibacterial activities.

关 键 词：氯苯基 衍生物 噻二嗪 三唑 抗菌活性 合成 化合物结构 缩合反应 元素分析 抑制活性 苯乙酮 ^1H NMR IR 

分 类 号：O626.1[理学—有机化学]