雌激素和雌激素受体调节剂对去卵巢大鼠食物奖赏的影响  

Effects of estradiol,conjugated estrogen and raloxifene on the reward of food intake in the overiectomized rats

作　　者：张宜生[1] 赖苗军[2] 李小艳[2] 唐甩恩[2] 张富强[2] 谢建华[3] 

机构地区：[1]浙江大学医学院附属妇产医院,杭州宁波市第一医院310006 [2]宁波微循环与莨菪类药研究所 [3]宁波市第一医院

出　　处：《中国行为医学科学》2005年第4期298-300,共3页Chinese Journal of Behavioral Medical Science

基　　金：宁波市医学科技项目(2003014)

摘　　要：目的观察雌二醇、结合雌激素和雌激素受体调节剂对去卵巢大鼠摄食行为的影响。方法摄食行为应用固定比例1的食物强化训练程序, 2%蔗糖水作糖水偏爱试验。结果雌性SD大鼠行双侧卵巢切除后1月体重较假手术组明显增加,自发活动度减少,摄食行为反应没有差异;再经过雌二醇或雷诺昔芬治疗1月后每小时有效摄食反应率为44±36和131±42,均较手术对照组的209±14明显减少(P<0. 05);结合雌激素治疗组的摄食反应率较手术组没有明显差异;雌二醇和结合雌激素治疗后动物糖水偏爱和消耗增加。结论雌二醇、结合雌激素和雌激素受体调节剂通过不同作用方式调节去卵巢大鼠的摄食奖赏行为。ObjectiveTo investigate the effects of the estradiol, conjugated estrogen and raloxifene on the food intake behavior, locomotor activity and sucrose choice in the ovariectomized rats. MethodsFood pellet delivery was administered under the fixed ratio 1 schedule of reinforcement, and sucrose water preference was used the 2 % sucrose solution. Results The body weight was increased and locomotor activity was decreased, but the responding for food intake was unchanged in the ovariectomized rats on 1 month after surgery. Responding for food on the active nose poke during the 1 hour test was 44±36 or 131±42 after either estradiol or raloxifene treatment for 1 month respectively, which was lower than that of saline treatment in the ovariectomized rats (P<0.05). In contrast, the conjugated estrogen treatment did not change the responding for food intake.Both preference and increasing intake of sucrose solution were observed in the estradiol- and the conjugated estrogen-treated rats.Conclusion The results provide the evidence that estradiol, conjugated estrogen or raloxifene has the different pathway to regulate the primary reinforcement of food taking.

关 键 词：雌激素受体调节剂 去卵巢大鼠 结合雌激素 雌性SD大鼠 摄食行为 卵巢切除后 雌二醇 训练程序 食物强化 行为反应 雷诺昔芬 奖赏行为 作用方式 反应率 糖水 手术 活动度 对照组 治疗组 治疗后 

分 类 号：R96[医药卫生—药理学]