多发家系精神分裂症患者血浆肿瘤坏死因子及白介素6水平的意义  

Multigene family study on plasma levels of TNF-α and interleukin-6 in schizophrenia

作　　者：祁富生[1] 杨建立[1] 贾福军[1] 

机构地区：[1]新乡医学院第二附属医院精神科,新乡453002

出　　处：《中国行为医学科学》2005年第4期304-306,共3页Chinese Journal of Behavioral Medical Science

基　　金：河南省医学科技创新人才工程项目(2000015)

摘　　要：目的检测精神分裂症多发家系成员血浆肿瘤坏死因子α(TNF-α)和白介素6(IL-6)的水平,分析其在精神分裂症的病因与发病机制中的作用。方法采用酶联免疫吸附法(ELSIA)检测43个精神分裂症多发家系181名成员(精神分裂症患者72名)和40名健康对照的血浆TNF-α和IL-6水平。结果精神分裂症患者组血浆TNF-α水平为(62. 51±33. 26)pg/ml,明显低于非血亲和正常对照组(P<0. 05),IL-6水平为(52. 58±27. 28)pg/ml,未见组间差异;发作期患者TNF α为( 52. 06±24. 21 )pg/ml,明显低于缓解期患者(P<0. 05),而IL-6为(64. 05±26. 58)pg/ml,明显高于缓解期患者(P<0. 05);TNF α水平与阴性症状N分呈负相关, (r=-0. 320, P=0. 030 ),而IL-6水平与阴性症状呈正相关(r=0. 429, P=0. 003);Ⅱ型患者IL-6水平为(72. 97±25. 97)pg/ml,Ⅰ型患者为(41. 42±22. 10)pg/ml,Ⅱ型患者明显高于Ⅰ型患者和非血亲正常对照组(P<0. 01)。结论TNF-α、IL-6在家族性精神分裂症的发病中有一定作用,IL 6仅与Ⅱ型精神分裂症或阴性症状有关。ObjectiveTo study the effects of the tumor necrosis factor alpha(TNF-α) and interleukin-6(IL-6) on schizophrenia by evaluating their plasma levels. MethodsUsing enzyme-linked immuno-sorbent assay, TNF-α and IL-6 plasma levels of were measured in 43 schizophrenic patients and their family numbers(n=138) and 40 healthy controls. ResultsTNF-α plasma levels(62.51±33.26)pg/ml in schizophrenic patients were significantly lower than in healthy controls(52.58±27.28 pg/ml)(P<.05), and there was no significant difference in IL-6 between the two groups. TNF-α plasma levels(52.06±24.21pg/ml) in upset patients were significantly lower than relieved ones(64.05±26.58pg/ml)(P<0.05), and while IL-6 was significantly higher. TNF-α plasma levels in schizophrenic patients has negative relations with N scores in Negative Symptom Scale (r=-0.320,P=0.030) and while IL-6 has positive relations(r=0.429, P=0.003).IL-6 in typeⅡschizophrenic patients(72.97±25.97 pg/ml) was higher than in typeⅠand healthy controls(41.42±22.10 pg/ml)(P<(0.01)).ConclusionTNF-α and IL-6 play a role in schizophrenia. IL-6 only has relation with typeⅡschizophrenia or negative symptoms.

关 键 词：精神分裂症患者 多发家系 水平 白介素6 血浆肿瘤坏死因子Α 家族性精神分裂症 6(IL-6) 血浆TNF-Α 酶联免疫吸附法 Ⅱ型精神分裂症 正常对照组 阴性症状 家系成员 发病机制 缓解期 ml 组间差 发作期 负相关 正相关 检测 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R581.1[医药卫生—临床医学]