胃癌中E-cadherin/catenins复合物的表达  

Expression of E-cadherin/catenin complex in human gastric cancers

作　　者：周辉[1] 翟博[2] 郑向民[1] 胡志前[1] 王毅[1] 

机构地区：[1]第二军医大学长征医院普通外科,上海200003 [2]解放军第401医院普通外科,青岛255071

出　　处：《第二军医大学学报》2005年第4期432-435,共4页Academic Journal of Second Military Medical University

摘　　要：目的:探讨E-cadherin/catenins复合物在胃癌中的表达及其与组织病理学特征和胃癌侵袭、转移等指标间的关系.方法:用EnVision法检测67例胃癌术后标本及10例正常胃黏膜标本中E-cadherin/catenins复合物的联合表达情况,并比较胃癌不同病理学特征及是否伴侵袭转移的标本间各指标表达率的差异.结果:10例正常胃黏膜标本中E-cadherin和α-,β-,γ-catenin以及P120分子均正常表达;而胃癌组织中上述5种分子的阳性表达率分别为56.6%、61.2%、55.2%、55.2%和59.7%.这5种分子的表达阳性率在胃癌的不同Borrmann分型(Ⅰ～Ⅳ型),不同分化程度(高、中、低),不同组织学类型(肠型和弥漫型,除β-catenin外),以及有无淋巴结转移之间均存在显著性差异(P＜0.05),但在胃癌是否有腹膜播散以及是否有远处转移之间均无显著性差异.E cadherin与α-,β-,γ-catenin和P120的表达趋势一致.结论:E-cadherin,α-,β-,γ-catenin和P120的表达减少与胃癌的发生和发展有关.Objective:To investigate the relationship between expression of E-cadherin/catenin complex and the histopathological feature, invasion and metastasis of human gastric cancer.Methods: The immunohistochemical staining of E-cadherin/catenin complex was performed using EnVision method in 67 specimens of human gastric cancer and 10 normal controls. Results: E-cadherin, α-, β-, γ- catenin, and P120 were co-located on the cell membrane of normal gastric mucosal tissue, while their expressions in gastric cancer were 56.6%,61.2%,55.2%,55.2% and 59.7% of those in normal tissue,respectively. The expressions of E-cadherin/catenin complex, except for β-catenin, were significantly correlated to different histological types(intestinal type and diffuse type). Additionally, the expressions of all above 5 molecules were significantly correlated to the differentiation degree, Bormann type and lymph node metastasis, but not to the peritoneal spreading and distant metastasis. It was also found that the expression of E-cadherin was consistent with the expression of all 4 catenins. Conclusion: The reduced expression of E-cadherin/catenin complex plays an important role in the development and progression of gastric cancer.

关 键 词：胃癌 E-cadherin/catenins复合物 病理学 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]