α-环糊精/水杨酸等包络物的NMR自扩散研究  

Interactions between α-Cyclodextrin and Small Organic Molecules Like Salicylic Acid Studied by NMR Diffusion Measurements

作　　者：彭敏[1] 孔旭新[1] 张惠平[1] 陈群[1] 

机构地区：[1]华东师范大学物理系教育部光谱学与波谱学重点实验室,上海200062

出　　处：《波谱学杂志》2005年第2期141-147,共7页Chinese Journal of Magnetic Resonance

基　　金：上海市纳米专项基金(0252NM011);教育部优秀青年教师教学与科研奖励基金资助.

摘　　要：用脉冲梯度场NMR测量自扩散系数的方法研究了水杨酸、水杨酸根、苯酚及苯甲酸根和α-环糊精(α-CD)形成包络物的相互作用.研究发现4种客体的扩散系数均随着环糊精含量增加而减小.利用测得的扩散系数计算出了4种客体和环糊精形成包络物的平衡常数,发现平衡常数随空间位阻变小而变大,同时也随着疏水性增强而增大,该结果和2D-ROESY(RotatingFrameOverhauserEffectSpectroscopy)谱均表明,在水杨酸等客体与α-环糊精相互作用过程中,芳香环与环糊精内腔的疏水相互作用起主导作用,不同客体和α-环糊精的结合比均为1∶1.The interactions between α-cyclodextrin and four ligands (salicylic acid, salicylate, phenol and benzoate) was studied by NMR diffusion measurements. The diffusion coefficients of the ligands in the solution, which reflects the affinity of association between α-cyclodextrin and them, were found to decrease as the concentration of α-cyclodextrin increased. Together with 2D-ROESY experiments, it was demonstrated that in forming inclusion complex, the hydrophobic interaction is predominant among various possible interactions between α-cyclodextrin and the ligands.

关 键 词：Α-环糊精 包络物 NMR 疏水相互作用 平衡常数 自扩散系数 脉冲梯度场 Frame 水杨酸根 苯甲酸根 系数计算 空间位阻 作用过程 主导作用 客体 疏水性 芳香环 

分 类 号：O636.12[理学—高分子化学] TQ463.4[理学—化学]