槲皮素磷酸酯钾对大鼠急性脑缺血再灌损伤的保护作用  

The protection of PQP against acute cerebral ischemia-reperfusion injuries in rats

作　　者：冯贵龙[1] 汤允昭[1] 王志平[1] 陶然[1] 郝一彬[1] 

机构地区：[1]山西医学院药理教研室

出　　处：《中国药理学通报》1994年第3期204-206,共3页Chinese Pharmacological Bulletin

摘　　要：用四动脉结扎法造成大鼠急性全脑缺血．４５ｍｉｎ缺血后再灌１ｈ造成再灌损伤模型。槲皮素磷酸酯钾在缺血前５ｍｉｎ及再灌前５ｍｉｎ各静注一次（２０ｍｇ·ｋｇ－１）·可减轻脑水肿并缓解脑损伤时ＣＫ的释放．保护ＳＯＤ的活性及降低脑组织ＭＤＡ的升高。提示槲皮素磷酸酯钾对脑缺血再灌损伤有保护作用。此作用可能与保护ＳＯＤ活性．抑制自由基的产生或直接清除自由基有关。The reperfusion injuries were performed by 45 min four-vessel occlusion and 1hsubsequent release in rats.Potassium quercetinphosphate(PQP),20 mg·kg-1 iv 5 min beforecomplete ischemia and the second one 5 min before release,declined brain edema formation(P<0.01),reduced the rise of lipid peroxidase(P<0.05),and suppressed the reduction in bothcreatine phosphokinase(CK)(P<0.01)andsuperoxide dismutase(SOD)activity( P <0.01)in brain tissue.The results suggest thatthe mechanism of the protective effects of PQPbe associated with the inhibition of the generation of oxygen free radicals, with the preventionof inactivation of SOD and(or) with the directscavenging of oxygen free radicals in tissues.

关 键 词：磷酸酯钾 脑缺血 再灌注损伤 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学]