乙酰水杨酸－聚－α，β－DL－（2－羟乙基）天冬酰胺共价复合体的合成  

SYNTHESIS OF ACEITYLSALICYLIC ACID-POLY-α,β-DL-(2-HYDROXYLETHYL)ASPARTIC AMIDE COVALENT COMPLEX

作　　者：单达先[1] 朱加进[1] 陈启琪[1] 褚建波[1] 

机构地区：[1]浙江医科大学药学系有机化学教研室,浙江医科大学药学系分析化学教研室

出　　处：《中国药物化学杂志》1994年第4期279-281,共3页Chinese Journal of Medicinal Chemistry

摘　　要：本文利用可生物降解的聚－α，β－ＤＬ－（２－羟乙基）天冬酰胺（ＰＨＥＡ）作为高分子载体和乙酰水杨酰氯在吡啶催化下缩合，成为聚天冬酰胺－乙酰水杨酸共价复合体，经用ＮａＯＨ溶液回流全水解后，由高效液相法测得乙酰水杨酸的接入率为３０％（ｗ／ｗ）．文中还对乙酰水杨酰氯的制备方法作了改进，收率为７５．６％。Poly-DL-aspartic amide-acetylsalicylic acid covalent complex was synthesized by applying biodegradable poly-α,β-DL-(2-hydroxylethyl)aspartic amide as a carrier to react with acetylsalicylyl chloride in the presence of pyridine. The loaded degree of acetylsalicylic acid was determined to be 30% by means of HPLC after hydrolysizing the complex thoroughly.An improved method of preparation of acetylsalicylyl chloride was also described in this paper.

关 键 词：聚天冬酰胺 乙酰水杨酸 共价复合体 天冬氨酸 

分 类 号：TQ463.26[化学工程—制药化工]