AHH诱导力与肺癌易感性的研究  

Susceptibility to lung cancer is associated with AHH inducibility

作　　者：章龙珍[1] 唐天友[1] 曹远东[1] 杜秀平[1] 张旭光[1] 朱振华[1] 

机构地区：[1]徐州医学院肿瘤防治研究所,江苏徐州221006

出　　处：《徐州医学院学报》2005年第3期191-195,共5页Acta Academiae Medicinae Xuzhou

基　　金：江苏省教委自然科学基金资助项目(01KDJ320033)

摘　　要：目的探讨芳烃羟化酶(AHH)诱导力与肺癌易感性的关系。方法采用AHH直接测定法,检测44例肺癌患者(肺癌组)、24例肺部良性病变患者(对照组)外周血淋巴细胞中AHH的诱导力。结果①肺癌组高诱导力者显著多于对照组(P<0.01),以AHH低诱导力者患肺癌的比值比(oddsratio,OR)为1.00,则中诱导力者OR为1.98(95%CI0.72～7.60),高诱导力者OR为7.00(95%CI1.34～27.25)。②AHH高诱导力的OR为3.40(95%CI1.49～7.76),与腺癌及其他组织学类型无明显的相关性。③吸烟能增加肺癌发病的相对危险度,并与AHH高诱导力型之间有协同作用;以AHH低诱导力非吸烟者患肺癌的OR为1.0,则AHH高诱导力吸烟者患肺癌的OR为9.00(95%CI1.07～75.90)。结论①AHH诱导力存在个体差异,与肺癌的相对危险度有关。②高诱导力型主要增加肺鳞癌发病的相对危险度,与吸烟有正协同作用。Objective To investigate the relationship between aryl hydrocarbon hydroxylase (AHH) inducibility and susceptibility of lung cancer.?Methods BA as a carcinogen was used to induce the expression of AHH in the lymphocytes collected from 44 lung cancer patients and 24 non-tumor patients.The level of AHH was measured directly according to Dong et al.?Results ①The frequency distribution of AHH inducibility was different between lung cancer patients and control patients(P<0.01).The relative risk of developing lung cancer (in odds ratio, OR) was 7.00-fold higher in the patients with high AHH inducibility than in those with low AHH inducibility (95%CI 1.34-27.25).②The AHH inducibility was not related to the histopathology of the lung cancer.③Cigarette smoking increased the risk of developing lung cancer. The OR in smoking high AHH inducibility patients was 9.00-fold higher than in non-smoking low AHH inducibility patients (95%CI 1.07-75.90).?Conclusion ①AHH inducibility varies between individuals.It correlates with the risk of developing lung cancer.②High AHH inducibility,especially alongside cigarette smoking,raises the risk of developing lung squamous cell carcinoma.

关 键 词：肿瘤 易感性 芳烃羟化酶 肺癌 AHH 诱导力 

分 类 号：R734.2[医药卫生—肿瘤]