血清IL-6、TNF-α测定对急性重症胰腺炎预后评价的意义  

Evaluation of the prognostic role of serum TNF-α and IL-6 in patients with severe acute pancreatitis

作　　者：曲永柏[1] 董琦[2] 隋武[1] 徐彦[1] 

机构地区：[1]山东省烟台市莱阳中心医院,山东烟台265200 [2]中南大学湘雅三医院,湖南长沙410013

出　　处：《宁夏医学杂志》2005年第6期383-385,共3页Ningxia Medical Journal

摘　　要：目的研究血清白介素-6(IL-6)和肿瘤坏死因子(TNF-α)与急性重症胰腺炎预后的关系。方法将Ranson’s评分3-5分的50名急性胰腺炎患者分为Ⅰ组(3分)17例、Ⅱ组(4分)18例、Ⅲ组(5分)15例,采用双抗体夹心ELISA法检测入院1、2、7天血清IL-6和TNF-α的水平,并以同期入院的20例因腹痛入院的非胰腺炎患者为对照组进行比较。结果Ⅰ、Ⅱ、Ⅲ组血清IL-6和TNF-α水平明显高于对照组(P<0.01),Ⅲ组明显高于Ⅰ、Ⅱ组(P<0.01)。死亡患者较幸存患者第1、2、7天IL-6和TNF-α持续处于升高水平(P<0.01)。结论血清IL-6、TNF-α反映了急性重症胰腺炎的病情严重程度,可作为预后估测的有效指标之一。Objective To study the relationship between serum levels of interleukins IL-6,TNF-α and the prognosis of patients with acute severe pancreatitis.Methods 50 patients diagnosed as severe acute pancreatitis were divided into Group Ⅰ 17 cases,Ⅱ 18 cases,Ⅲ 15 cases with Ransons criteria of 3,4,and 5 respectively. Serum IL-6,TNF-α values were measured at 1th, 2th, 7th days.A control group of 20 patients with pain abdomen of non-pancreatitis orgin were investigated, studied and closely followed up simultaneously.Results Both IL-6 and TNF-αwere significantly increased in patients with severe acute pancreatitis as compared to patients of non-pancreatic pain abdomen (P<0.01).The levels were significantly higher in Group Ⅲ when compared with Group Ⅰ and Ⅱ.The levels of serum IL-6 and TNF-αwere remained higher in patients dead than in the survivals at 1th, 2th, 7th day.Conclusion The determination of serum levels of IL-6,TNF-α may be served as effective marks to predict the outcome of severe acute pancreatitis.

关 键 词：胰腺炎 白介素-6 肿瘤坏死因子-Α 

分 类 号：R576[医药卫生—消化系统]