胃粘膜上皮异型增生的增殖细胞核抗原免疫组织化学研究  

Immunohistochemical Study of ProlferatingCell Nuclear Antigen Cyclin in Gastric Epithelial Dysplasia

作　　者：王梅先[1] 吴亚军[1] 张荫昌[1] 刘松[1] 任莉[1] 

机构地区：[1]中国医科大学肿瘤研究所胃癌研究室,新金县第一人民医院病理科

出　　处：《中国医科大学学报》1994年第5期431-433,共3页Journal of China Medical University

摘　　要：ＡＢＣ免疫酶标半定量分级法表明，增殖细胞核抗原（ＰＣＮＡ）在胃粘膜上皮异型增生的阳性分级表达高于浅表胃炎、低于胃癌（Ｐ＜０．０５）。其中再生型、隐窝型及腺瘤型异型增生的阳性分级表达呈递减关系（Ｐ＜０．０５），而且三者阳性细胞的分布各有特点。ＰＣＮＡ的原位检测，是胃粘膜上皮异型增生及其恶性变的较好辅助诊断指标。half─ quantitive immunohistochemical study denoted that the positive grade of PCNA in gas-tric dysplastic epithelia was strikingly higher than that of chronic gaastritis but lower than that of gas-tric carcinoma(P<0.05).Among various types of gastric dysplasia,the PCNA positive rate decreasedgraduately in regenerative type,cryptal type and adenomatous type of the dysplasia(P<0.05).At thesame time,distribution of the positive cells had their own characteristics. The authors found that insituexaminatidn using PCNA immunocytochemical probe was a favourable diagnostic index for evaluation ofthe malignant potential of gastric dysplasias.

关 键 词：增殖细胞核抗原 胃粘膜增生 胃肿瘤 病理学 

分 类 号：R735.2[医药卫生—肿瘤]