SRD5A2基因A49T多态性与前列腺癌风险性关系的研究  

Association between A49T polymorphism of SRD5A2 gene and risk of prostate cancer

作　　者：佟明[1] 艾军魁[1] 袁亦明[1] 殷毅[1] 周利群[1] 辛殿旗[1] 李鸣[1] 那彦群[1] 

机构地区：[1]北京大学第一医院泌尿外科

出　　处：《中华医学杂志》2005年第19期1319-1321,共3页National Medical Journal of China

基　　金：国家自然科学基金资助项目(30070755)

摘　　要：目的探讨SRD5A2基因多态性A49T(49密码子苏氨酸替代丙氨酸)与前列腺癌预后的关系。方法用Mwo1限制性内切酶对A49T多态性位点进行酶切鉴定,观察112例前列腺癌组织和89例前列腺增生组织的A49T的AA、AT、TT基因型多态性分布情况的差异及该多态性与前列腺癌患者的年龄、前列腺特异性抗原(PSA)、F/T、Gleason评分、分期的关系。结果前列腺癌与前列腺增生组的A49T基因频度风险无显著性差异(P>0.05)。前列腺癌组年龄明显高于增生组(P<0.05),AT+TT型患者发病年龄明显低于AA型(P<0.05),AT+TT基因型可能预后较差。AT+TT基因型患者Gleason评分平均水平明显高于AA基因型(P<0.05)。用分段评价PSA、Gleason评分、T分期、年龄,结果均与两种基因型无相关性,提示基因型与预后无显著性差异。AA、AT+TT基因型与Gleason评分的关系,等级评分(2～10分)与分段评价法(≤6、>6分)结果不一致。结论用等级评分与分段评价法结果不一致。等级评分法比分段法或许更能反映Gleason评分与A49T基因型的关系,更适用于估计预后。Objective To investigate the association between A49T polymorphism of SRD5A2 gene and risk of prostate cancer. Methods PCR was used to examine the A49T polymorphisms of SRD5A2 gene in the tissues of prostate cancer resected from 112 patients (CaP group) and the specimens of benign prostate hyperplasia (BPH group) resected from 89 patients. The association of A49T polymorphism with age of onset, FPSA, TPSA, F/T, T stage, and Gleason score were analyzed. Results There was no significant difference in A49T polymorphism between the CaP and BPH groups (P>0.05). The average age of CaP patients was significantly higher than that of the BPH patients (P<0.05). In the CaP patients, the Gleason score was significantly higher, and the age of onset was significantly lower in the AT+TT genotype than in the AA genotype (both P<0.05)2. The age of onset of the AA+AT group was significantly lower than that of the AA group (P<0.05). Conclusion AA+AT genotype may be of worse prognosis, however, without significant difference. Rank scoring may reflect the relation between Gleason score and A49T genotype and estimate the prognosis better than two-level discrete evaluation.

关 键 词：SRD5A2基因 A49T多态性 前列腺癌 等级评分法 预后 

分 类 号：R737.25[医药卫生—肿瘤]