胃肠道间质瘤中p27和细胞周期素D1蛋白的表达及临床意义  

Expression and clinical significance of p27 protein and cyclinD1 protein in gastrointestinal stromal tumors

作　　者：杨晓东[1] 左敏[2] 潘凯[1] 

机构地区：[1]暨南大学第二附属医院深圳市人民医院胃肠外科,深圳518020 [2]暨南大学第二附属医院深圳市人民医院病理科,深圳518020

出　　处：《中华医学杂志》2005年第19期1352-1354,共3页National Medical Journal of China

基　　金：深圳市科技局资助项目(200404042)

摘　　要：目的研究p27和细胞周期素D1蛋白在胃肠道间质瘤中的表达及其与间质瘤临床病理特征的关系。方法收集48例手术切除的胃肠道间质瘤标本,同时取距瘤灶>5cm的正常组织,应用免疫组织化学SP法检测肿瘤组织及正常组织中p27和细胞周期素D1蛋白的表达。结果48例胃肠道间质瘤中p27和细胞周期素D1蛋白阳性表达率分别为54.16%和58.33%。p27蛋白的低表达与间质瘤的分化程度呈负相关(P<0.01),与间质瘤复发呈负相关(P<0.01)。p27和细胞周期素D1蛋白在胃肠道间质瘤的表达呈正相关(r=0.573,P<0.01)。结论p27和细胞周期素D1蛋白与胃肠道间质瘤的发生、发展有关,检测p27和细胞周期素D1蛋白可作为评估恶性程度和判断预后的重要指标。Objective To investigate the expression of p27 and cyclin D1 protein in gastrointestinal stromal tumors (GIST), and discuss the relationship between their expression and clincopathological characteristics.Methods Immunohistochemical staining was used to detect the expression of p27 and cyclin D1 in 48 cases of GIST and corresponding normal tissues.Results In 48 cases GIST, the expression of p27 and cyclin D1 protein were 54.16% and 58.33% respectively. The low level expression of p27 protein was inversely correlated with the degree of differentiation and tumor recurrence of GIST (both P<0.01). The expression of p27 protein was positively relatied to that of cyclin D1(r=0.573, P<0.01).Conclusion^These data shows the expression of p27 and cyclin D1 expression are related to the ontogenesis and progression of GIST. p27 and cyclin D1 may be prognostic indicators in GIST.

关 键 词：胃肠道间质瘤 P27 细胞周期素D1蛋白 表达 预后 

分 类 号：R735[医药卫生—肿瘤]