胃粘液腺癌149例临床病理学特点  

Clinicopathological Characteristics of 149 Patients with Mucinous Gastric Carcinoma

作　　者：陶冀 游廉 王锡山[2] 

机构地区：[1]哈尔滨市第五医院普外二科,哈尔滨市150040 [2]哈尔滨医科大学附属第三医院

出　　处：《中国肿瘤临床》2005年第11期651-653,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:比较胃粘液腺癌(Mucinousgastriccarcinoma,MGC)不同分期的临床病理学差异,探讨影响MGC预后的临床病理学特征。方法:分析1982年1月～1997年12月收治的MGC患者149例的临床病理及其预后。结果:MGC更易发生浆膜浸润(Ⅲ、Ⅳ期S2+S3:67.5%);浸润性更强(Ⅰ+Ⅱ期T3:6.2%;Ⅲ+Ⅳ期T3:44.4%);中晚期更易腹膜种植(P2+P3:30.7%);中晚期更易发生淋巴结转移(N1+N2:80.3%);根治性切除率早期明显高于中晚期(P<0.005);Ⅰ+Ⅱ期5年生存率早期明显提高(53.1%),中晚期仅为13.7%,两者之间比较有明显差别(P<0.005)。结论:不同时期MGC临床生物学行为不尽相同,其预后不良的原因与确诊时病期晚,发生浆膜浸润率、淋巴结转移率、腹膜播散率高和根治性切除率低有关。Objective: To evaluate clinicopathological difference in varying stage of patients with mucinous gastric carcinoma (MGC) and to study clinico-pathological characteristics, which influenced the prognosis of MGC. Methods: A total of 149 cases with MGC were admitted for treatment from January 1982 to December 1997. Their clinico-pathological examination and prognosis were analyzed. Results: Infiltration of serosa occurred easily in the patients with MGC (intermediate and advanced stage S2+S3: 67.5%), and MGC had stronger infiltration(Ⅰ+Ⅱstage T3 6.2%; Ⅲ+Ⅳstage T3 44.4%). Inplantation of peritoneum occurred easily in intermediate and advanced stage (P2+P3: 30.7%). Metastasis of lymph occurred easily in intermediate and advanced stages (N1+N2 80.3%); The rate of radical resection in early stage was higher than it in intermediate and advanced stage(P<0.005). Survival rate for five years in early stage was higher than it in intermediated and advanced stages. There was a significant difference between early stage and another two stages. Conclusion: Biological action is different in every stage of MGC. Bad prognosis is related with the time of correct diagnosis, infiltration of serosa, metastasis of lymph node and a lower rate of radical resection.

关 键 词：胃肿瘤 粘液腺癌 病理学 临床特点 预后 

分 类 号：R735.2[医药卫生—肿瘤]