奥硝唑联用醋酸氯己定对白色念珠菌的体外抗菌活性考察  

The Study on Antibacterial Activity of Ornidazole Combined with Chlorhexidine Acetate Against Candida Albicans in Vitro

作　　者：舒凌玲[1] 陈雅[1] 吴畏[1] 杨征[1] 

机构地区：[1]第三军医大学野战外科研究所大坪医院药剂科,重庆400042

出　　处：《中国药业》2005年第5期27-28,共2页China Pharmaceuticals

摘　　要：目的:考察奥硝唑与醋酸氯己定联合用药对白色念珠菌的体外抗菌活性。方法:采用棋盘法设计,琼脂平板稀释法测定最低抑菌浓度(MIC)值;计算分级抑菌浓度(FIC)指数并判定联合效应,FIC≤0.5为协同作用,0.5<FIC≤1为相加作用,1<FIC≤2为无关作用,FIC>2为拮抗作用。结果:奥硝唑与醋酸氯己定联合应用,其MIC显著降低,FIC≤0.5。结论:奥硝唑与醋酸氯己定联合用药后,对白色念珠菌体外抗菌活性有协同作用。Objective:To evaluate the antibacterial activity of ornidazole combined with chlorhexidine acetate against candida albicans in vitro.Methods:The protocol was designed by checkerboard method.MICs of ornidazole combined with chlorhexidine acetate against candida albicans were determined by broth dilution method.FIC index was calculated according to MIC results.The FIC index less than 0.5 is synergism,from 0.5 to 1 is additivity,from 1 to 2 is antagonism,more than 2 is little autonomy.Results:Ornidazole combined with chlorhexidine acetate,MIC significantly descends and FIC index is less than 0.5.Conclusion:Ornidazole combined with chlorhexidine acetate against candida albicans manifests synergism.

关 键 词：奥硝唑 醋酸氯己定 白色念珠菌 分级抑菌浓度 体外抗菌活性 

分 类 号：R915[医药卫生—微生物与生化药学] R988.2[医药卫生—药学]