脑胶质瘤组织PCNA和Ki-67及p53的表达研究  

Expressions of PCNA, KI-67 and p53 in human glioma

作　　者：王家银[1] 关向宏[1] 战雪梅[1] 罗兵[2] 

机构地区：[1]临沂市人民医院病理科,山东临沂276003 [2]青岛大学医学院病原生物学教研室,山东青岛266012

出　　处：《肿瘤防治杂志》2005年第10期753-755,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨PCNA、Ki-67和p53与胶质瘤的分级及预后的关系.方法:采用免疫组化SP法检测48例脑胶质瘤标本和对照组10例标本PCNA、Ki-67和p53的表达.结果:48例胶质瘤标本中,PCNA、Ki-67和 p53表达阳性率分别为85.4%(41/48)、68.8%(33/48)和45.8%(22/48);对照组10例标本均不表达PCNA、Ki-67和p53,两组比较,差异有统计学意义,χ2=7.348～23.563,P<0.01.结论:胶质瘤中PCNA、Ki-67及p53的阳性表达率与其恶性度相关,均可作为判断胶质瘤恶性程度及预后的指标.OBJECTIVE: To determine the relationship between the expressions of PCNA, Ki-67 and p53 and the grading or prognosis of the gliomas.METHODS:The expressions of PCNA, Ki-67 and p53 in 48 samples of human gliomas and 10 normal tissue specimens were detected by the immunohistochemistry method (SP).RESULTS:In the 48 gliomas studied, PCNA in 85.4%(41/48), Ki-67 in 68.8%(33/48) and p53 in 45.8%(22/48). None of the normal tissue specimens expressed PCNA, Ki-67 and p53, χ~2=7.348-23.563,P<0.01.CONCLUSIONS:PCNA, Ki-67 and p53 express in high percentage of gliomas. The expressions of PCNA, Ki-67 and p53 in gliomas may be used as tumor markers evaluating the histograde, clinical stage and prognosis of human glioma.

关 键 词：脑肿瘤/代谢 神经胶质瘤/代谢 增殖细胞核抗原 蛋白质P53 免疫组织化学 

分 类 号：R739.4[医药卫生—肿瘤]