二联苯和氨基酸构建的大环化合物自组装研究  

Self-assembly of Biphenyl-bridged and Amino Acid-based Macrocycle Compounds

作　　者：郭炜[1] 米学玲[1] 王璟[1] 何家骐[1] 程津培[1] 

机构地区：[1]南开大学化学系

出　　处：《高等学校化学学报》2005年第6期1086-1089,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20072020和29832041);国家重点基础研究发展计划(批准号:G2000078100)资助.

摘　　要：以二联苯作为模板,设计并合成了3个二联苯和氨基酸构建的大环化合物.晶体结构结果研究发现,在固态,这些大环化合物分别组装成了管状、三维网状和链状的超分子结构,其中,C—H…O氢键在维持这些大环的组装方面发挥了重要作用.这将有助于进一步增加对分子自组装、分子识别以及生物大分子的稳定性方面的理解.As part of our efforts aimed at developing molecular receptors and peptide conformational templates, we have conducted a research on design, synthesis, and application of structurally modified cyclopeptides. In this paper, we disigned and synthesized three biphenyl-bridged, amino acid-based macrocycles. The investigation of crystallograghic structures reveals that in the solid state, these macrocycles were assembled into twin-tube, 3D network and chain-like supramolecular structures, respectively, in which the C-H...O hydrogen-bonds play important roles. These findings may be helpful for understanding the role of the C-H...O hydrogen bonding in determining crystal packing, molecular recognition, and the structural stability of biological macromolecules.

关 键 词：大环化合物 二联苯 氨基酸 自组装 C—H…O氢键 

分 类 号：O625[理学—有机化学]