心痛定片剂与滴丸的人体生物利用度及药代动力学的研究  

Study on the bioavailability and pharmacokinetics of nifedipine tablets and pills in healthy volunteers

作　　者：徐凯建[1] 张慧君[1] 陆义诚[1] 吴琳华[1] 孙考祥[1] 胡君茹[1] 

机构地区：[1]哈尔滨医科大学临床药学药物研究所

出　　处：《中国医院药学杂志》1994年第3期106-108,共3页Chinese Journal of Hospital Pharmacy

摘　　要：本文采用高压液相色谱法测定心痛定片剂与滴丸的人体血药浓度。流动相：甲醇（色谱纯）─磷酸盐缓冲液（６０：４０），紫外检测波长２３５ｎｍ，以片剂为标准制剂，滴丸的相对生物利用度为１２２．０％。对片剂与滴丸的ＡＵＣ、Ｃｍａｘ、Ｔｍａｘ作ｔ检验，结果二者之间Ｃｍａｘ、Ｔｍａｘ有显著性差异（Ｐ＜０．０５），ＡＵＣ无显著差异（Ｐ＞０．０５），结果表明滴丸较片剂优良。he plasma concentrations of Nifedipine tablets and pills in healthy volunteers were determined by HPLC respectively.The mobile phase was methanol-phosphate buffer(60:40 ,UV detection wavelength was 235 nm. The relative bioavailabitityof pills was 122.0%as compared with the tablets. Through t-test,significant difference of Cmax ,Tmax between tablets andpills was found( p<0. 05)and no significant difference of AUC was found( p<0.05).The results showed that the pills ofNifedipin was better than tablets.

关 键 词：心痛定 高效液相色谱 生物利用度 

分 类 号：R914.1[医药卫生—药物化学]