胃癌组织血管内皮生长因子表达对胃癌生物学行为的影响  

Influence of VEGF and Ki-67 expression on biological behavior of gastric cancer

作　　者：王升[1] 吴本俨[1] 尤纬缔[1] 

机构地区：[1]中国人民解放军总医院南楼消化科,北京市100853

出　　处：《世界华人消化杂志》2005年第6期716-719,共4页World Chinese Journal of Digestology

摘　　要：目的:研究胃癌组织中血管内皮生长因子(vascular en- dothelial growth factor,VEGF)的表达与胃癌生物学指征之间的关系以及对预后的影响.同时研究细胞增生核抗原标记指数(Ki67-LI)在胃癌中的意义. 方法:选择有预后资料的胃癌术后患者77例,用免疫组织化学方法(二步法)检测胃癌组织中VEGF、Ki67的表达,综合分析上述指标的相关性以及与胃癌生物学行为和预后的关系. 结果:胃癌细胞VEGF的表达与肿瘤最大直径(P=0.011)、浸润深度(P=0.014)、淋巴结转移(P=0.017)、临床分期(P=0.001)相关,VEGF阳性组与阴性组Ki67-LI均值分别为562.8±118.3,436.82±142.2(P=0.0 005), 具有显著差异.VEGF对预后有影响,阳性组预后较差. Ki-67-LI与淋巴结转移(P=0.027)、临床分期(P=0.020) 以及预后(P=0.036)相关,Ki-67-LI高的胃癌容易发生淋巴结转移,进展快,恶性度高,预后差. 结论:VEGF可以促进肿瘤血管生成,进而促进肿瘤细胞增生,对预后产生不利影响.Ki-67-LI与肿瘤临床生物学行为以及预后相关,反映了肿瘤的恶性进程.AIM: To investigate the relationship between expression of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen Ki-67 and the biological behavior of gastric cancer. METHODS: The Ki-67 labeling index (Ki-67-LI)and VEGF expression in tumors were analyzed by immunonistochem-istry using specific antibodies. The relationship between each other, and their prognostic significance were evaluated. RESULTS: The intensity of VEGF staining was correlated with tumor maximum diameter (P= 0.011), depth of tumor invasion (P= 0.014), lymph node metastasis (P = 0.017) and tumor stage (P= 0.001). The Ki67-LI of VEGF positive group (562.8±118.3) was significantly higher than that of negative group (436.8±142.2)(P= 0.0 005). The prognosis of VEGF positive group was significantly worse than that of negative group. Ki67-LI was significantly correlated with lymph node metastasis(P= 0.027), tumor stage (P= 0.020) and prognosis(P= 0.036). CONCLUSION: VEGF promotes tumor angiogenesis and development. High Ki67-LI reflects active proliferation of tumor cells. Both indicate an unfavorable prognosis.

关 键 词：血管内皮生长因子 癌生物学行为 胃癌组织 免疫组织化学方法 淋巴结转移 临床生物学行为 VEGF factor 肿瘤血管生成 肿瘤细胞增生 临床分期 术后患者 标记指数 Ki67 胃癌细胞 综合分析 浸润深度 预后相关 核抗原 二步法 

分 类 号：R735.2[医药卫生—肿瘤]