结直肠癌中神经内分泌克隆对其预后的影响  

The prognostic value of human neuroendocrine clone on colorectal carcinoma

作　　者：杨晓东[1] 王杉[1] 孟会彦[2] 叶颖江[1] 虞有智[3] 姜可伟[1] 杨申[1] 曲军[1] 方伟岗[4] 

机构地区：[1]北京大学人民医院外二科外科肿瘤研究室,100044 [2]河北省医院普外科 [3]北京大学人民医院病理科,100044 [4]北京大学医学部

出　　处：《中华外科杂志》2005年第11期706-709,共4页Chinese Journal of Surgery

基　　金：北京市科委科学研究重点项目;教育部科学技术研究重点项目(02003)

摘　　要：目的探讨结直肠癌神经内分泌分化与结直肠癌预后的关系。方法对73例结直肠低分化腺癌的临床和随访资料进行回顾性分析,并应用免疫组化的方法检测嗜铬素A、突触素在肿瘤及转移淋巴结和远处转移组织的表达。结果73例结直肠低分化腺癌患者中有13例表现为神经内分泌分化(17.8%),且这组患者的1年生存率明显低于同时期的结直肠低分化腺癌组(P<0.05)。其转移淋巴结以及远处转移组织中以神经内分泌克隆为主。结论结直肠癌神经内分泌克隆是影响其淋巴结及远处组织转移的重要因素,它可能会成为判断结直肠癌预后的新的的指标及治疗靶点。Objective To demonstrate the prognostic value of neuroendocrine clone on colorectal carcinoma. Methods The immunochemistry methods were used to investigate the percent of neuroendocrine carcinoma in 73 human colorectal carcinoma. Retrospective analysis and follow-up were carried out in all patients. Results In all 73 cases of colorectal carcinoma, the total percentage of neuroendocrine carcinoma was 17.8%. Neuroendocrine carcinoma included 11 synapse positive, 6 chromogranin positive and 4 both positive. The major factors related to the prevalence of neuroendocrine carcinoma were sex, age, tumor location and Dukes′ stage. And the 1-year survival rate of the patients who suffered from neuroendocrine carcinoma is obviously lower than that of other colorectal carcinoma. Conclusions The neuroendocrine carcinoma is a special kind of human colorectal carcinoma, and neuroendocrine clone may be a new marker of the malignant potency. The neuroendocrine clone has its prognostic value and may be a novel therapeutic target.

关 键 词：结直肠癌 预后 克隆 神经内分泌分化 直肠低分化腺癌 转移淋巴结 远处转移 回顾性分析 随访资料 嗜铬素A 免疫组化 治疗靶点 组织 突触素 癌患者 生存率 

分 类 号：R735.34[医药卫生—肿瘤]