口服高氧液对急性运动性疲劳的防治作用及可能机制的初步探讨  

A preliminary study of hyperoxic solution taken orally on fatigue induced by exercise and its mechanism

作　　者：张惠[1] 刘春然[1] 王玲[1] 徐礼鲜[1] 

机构地区：[1]第四军医大学口腔医院麻醉科,西安710032

出　　处：《解放军医学杂志》2005年第6期488-489,共2页Medical Journal of Chinese People's Liberation Army

基　　金：国家科技部创新基金(编号00c26226110464);陕西省自然科学基金(编号99SM39)资助课题

摘　　要：目的　研究高氧液对急性运动性疲劳的防治作用及其机制。方法　选择士兵80名,随机分为口服高氧液实验组和口服平衡盐液对照组。运动方式为5 000m连续跑,在运动前30min以及运动2 000m和4 000m处,分别口服高氧液或平衡盐液250ml、150ml、150ml。在运动前和运动结束即刻分别抽取静脉血,检测乳酸含量、三磷酸腺苷酶活力、丙二醛含量、总抗氧化能力等指标。结果　高氧液实验组血清乳酸及丙二醛含量均明显低于对照组(P<0 05),三磷酸腺苷酶活力、总抗氧化能力与对照组比较均显著增高(P<0 05)。结论　高氧液有显著的抗急性运动性疲劳作用,其机制可能与高氧液增加氧供及抗脂质过氧化有关。Objective To investigate the antifatigue effect of hyperoxia solution and its mechanism. Methods Eighty soldiers were randomly divided into two groups: hyperoxic solution group and common balance salt solution group The exercise selected was 5000 meters constantly running. The soldiers of each group were respectively given hyperoxic solution or balanced salt solution 250ml thirty minutes before running; then each were respectively given orally 150ml hyperoxia solution or balanced salt solution at 2000 meters and 4000 meters, The soldiers were bled before running and after running immediately, and the contents of lactic acid and malondialdehyde,the general ability of antioxidation and the energy of adenosine triphosphate enzyme were determined instantly. Results The contents of lactic acid and malondialdehyde of hyperoxic solution group were significantly less than that of control group ( P <0 05); the general ability of antioxidation and the activity of adenosine triphosphate enzyme increased markedly ( P <0.05). Conclusion Hyperoxic solution possesses antifatigue effect, thus can improve moving capability. The mechanism may associate with the increased oxygen supply and anti lipid peroxidation effect

关 键 词：高氧液 疲劳 乳酸 腺苷三磷酸酶 丙二醛 

分 类 号：R337[医药卫生—人体生理学]