环氧合酶-2高表达与肝癌临床病理特征的关系  

The expression of COX-2 in primary hepatocellular carcinoma and its relation to clinicopathologic characteristic

作　　者：李胜保[1] 王小虎[1] 王强[1] 谢国建[1] 姜东升[1] 易建华[1] 吴清明[1] 

机构地区：[1]郧阳医学院附属太和医院,十堰442000

出　　处：《胃肠病学和肝病学杂志》2005年第3期262-264,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨COX2在肝癌中的表达及其与肝癌临床病理特征的关系。方法应用免疫组织化学方法(SP法)检测COX2在34例肝癌中的表达。结果COX2在肝癌中的表达率为82.4%(28/34),主要为肝癌组织的表达,而在癌旁正常组织中无表达。20例阳性表达COX2的肝癌中,分化良好的22例COX2表达水平为8.25±0.86,分化中等和分化差的6例COX2表达水平为6.11±1.02,比较差异显著(P<0.05),COX2的高表达水平与肝癌细胞分化程度有关,而与AFP高低、来源细胞及有无肝内转移无关。结论肝癌中COX2的高度表达与肝癌分化程度有关,COX-2可能是肝癌发生的早期事件之一。Objective To discuss the relationship of cyclooxygenase_2 (COX_2) expression in human primary hepatocellular carcinoma (HCC) with clinicopathologic characteris tic. Methods The COX_2 protein were examined in 34 HCC tissues and adjacent nontumorous tissu es by immunohistochemical technique. Results Twenty_eight of 34(82.4%) patients with HCC exhibited a positive staining.More intense staining of COX_2 in cancer tissue rather than non_cancerous tissue was observed in 22 of 28 (78%) patients with well different iated HCC,in 6 of 28(22%) with moderately differentiated and poorly differentiat ed HCC.The well_differentiated HCC expressed COX_2 protein (8.25±0.86) more s trongly than moderated and poor differentiated HCC (6.11±1.02) (P<0.05) ,But no correlation with serum AFP,cell types,inner of invasion. Conclusion The overexpression of COX_2 in well_differentiated H CC suggests that COX_2 may play a role in the early stages of hepatocarcinogensi s.

关 键 词：临床病理特征 环氧合酶-2 高表达 COX-2表达 免疫组织化学方法 癌细胞分化程度 癌旁正常组织 方法应用 肝癌组织 阳性表达 差异显著 肝内转移 来源细胞 肝癌发生 表达及 SP法 表达率 水平 AFP 

分 类 号：R735.2[医药卫生—肿瘤] R392.9[医药卫生—临床医学]