FEP与FEM方案双途径介入治疗原发性肝癌的临床对比研究  

Comparative study of FEP and FEM regimen combination with TACE plus PEI in the treatment of primary hepatic carcinoma

作　　者：张中冕[1] 田薇薇[1] 冯广森[2] 刘萍[1] 罗凤萍[1] 

机构地区：[1]郑州大学第二附属医院肿瘤科,郑州450003 [2]郑州大学第二附属医院放射科

出　　处：《胃肠病学和肝病学杂志》2005年第3期288-289,292,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的评价FEP与FEM两种化疗方案双途径介入治疗原发性肝癌的疗效及安全性。方法95例肝癌,男81例,女14例。年龄32～72岁(中位年龄46岁)。其中FEP组48例、FEM组47例。全部病例均采用动脉灌注及化疗栓塞技术,FEP组选用化疗药物5氟脲嘧啶,表阿霉素、顺铂,FEM组选用5氟脲嘧啶、表阿霉素、丝裂霉素,并联合经皮穿刺无水酒精注射。结果FEP组总有效率54.2%(26/48),中位生存期21.2个月。FEM组总有效率34%(16/47),中位生存期14.6个月。FEP组及FEM组病人1、2、3年生存率分别为89.6%、43.8%、29.2%及85.1%、29.8%、14.9%。FEP组及FEM组病人总有效率、中位生存期及3年生存率经统计学检验具有显著性差异(P<0.05)。结论双途径介入治疗对提高肝癌疗效有重要的临床价值,FEP方案较FEM方案为优。Objective To compare the efficacy and toxicity in the treatment of primary hepatic carcinoma with FMP and FEP regimen combination with TACE pl us PEI.Methods Ninety-five cases with primary hepatic carcin oma were selected,with the age ranged from 32 to 72 years(the average was 46 y ears ),including 81 males and 14 females. All cases were treated with FMP and FEP regimen combination with transcatheter arterial chemoembolization(TACE) and percutaneous ethanol injection therapy(PEI).Results The response rate were 54.2%(26/48) f or FEP regimen and 34%(16/47) for FEM regimen, respectively (p<0.05). Th e median survi val time of the FEP and FEM regimens were 21.2 months and 14.6 months, resp ectively (P<0.05. The survival rates in the 1,2,3-year follow-up were 89.6 %,43.8% 29.2% and 85.1%,29.8%, 14.9%, respectively. There was signific ant difference of survival rates in the 3-year follow-up (P<0.05). Conclusion The co-administration of th e interventional methods is very useful to increase the treatment effect, and FE P regimen is superior to FEM regimen.

关 键 词：原发性肝癌 FEM方案 介入治疗 临床对比研究 双途径 中位生存期 3年生存率 疗效及安全性 5-氟脲嘧啶 无水酒精注射 总有效率 表阿霉素 显著性差异 统计学检验 FEP方案 化疗方案 中位年龄 栓塞技术 动脉灌注 化疗药物 丝裂霉素 

分 类 号：R735.7[医药卫生—肿瘤] R735.205[医药卫生—临床医学]