复合骨形成蛋白治疗剂治疗根尖周病的动物实验研究  

Animal Experimental Study of the Treatment of Periapical Disease with Recombinant Human Bone Morphogenetic Protein-2 Composite

作　　者：彭华光[1] 汪竹平[2] 刘亭彦[1] 王铎[2] 

机构地区：[1]杭州师范学院临床医学院口腔教研室,浙江杭州310018 [2]山东大学口腔医院牙体牙髓科,山东济南250012

出　　处：《华西口腔医学杂志》2005年第3期204-207,共4页West China Journal of Stomatology

基　　金：山东省科委科研基金资助项目(413773)

摘　　要：目的观察复合重组人骨形成蛋白_2(rhBMP_2)治疗剂治疗狗牙实验性根尖周病的疗效。方法采用根管内封入内毒素细菌混合液的方法建立根尖周病动物模型,将由rhBMP_2、磷酸三钙、胶原和甲硝唑制成的复合rh BMP_2治疗剂作为根尖屏障用于狗牙实验性根尖周病的治疗,行X线及组织学观察治疗效果,同时设有载体组(根尖屏障材料不含rhBMP_2)和对照组(根尖屏障材料为氧化锌丁香油糊剂加牙胶尖)。结果复合rhBMP_2治疗剂具有X线阻射特性,实验组治疗根尖周病的有效率明显高于载体组和对照组;组织学观察显示,实验组根尖周组织新生活跃,修复质量明显优于载体组和对照组(P<0.05)。而且rhBMP_2治疗剂用量少,可操作性好。结论复合rh BMP_2治疗剂治疗根尖周病有较好的效果。Objective To investigate the effect of the treatment of periapical diseases with recombinant human bone morphogenetic protein (rhBMP_2) composite in dog models so as to provide basis for its clinical application. Methods The endotoxin_bacteria mixed fluid was injected into each root canal of the experimental teeth of dogs and the animal periapical disease models were built. The rhBMP_2 composite was mixed by rhBMP_2,TCP,collagen and metronidazole and used in the treatment of periapical diseases in dog models as root apex screen. The imageology and pathology research were went on. Results The effective rate of the experimental group was remarkably higher than that of the carrier group and the control group with remarkable statistical difference(P<0.05). The quality of the repair of tissue was obviously better than the two other groups. Conclusion The rhBMP_2 composite is a promising biological root_canal filling material.

关 键 词：重组人骨形成蛋白-2 根尖周病 根管治疗 

分 类 号：R781.34[医药卫生—口腔医学]