2-取代亚肼基-1,3-二硫杂环戊烷类化合物的合成及抗菌活性  

Synthesis and the antimicrobial activity of 2-(2'-substituted hydrazono)-1,3-dithiacyclopentane derivatives

作　　者：朱小康[1] 苟绍华[1] 张佩玉[1] 陈洪超[1] 

机构地区：[1]四川大学化学学院,四川成都610064

出　　处：《华西药学杂志》2005年第3期210-212,共3页West China Journal of Pharmaceutical Sciences

基　　金：四川省科技厅资助(No.01SG045-05)

摘　　要：目的为了寻找高效、低毒的农用杀菌剂,用超声波法合成新型的2-取代亚肼基-1,3-二硫杂环戊烷类化合物。方法以CS2、NH2NH2·H2O、BrCH2CH2Br为原料,在超声波辐射下合成中间体1,3-二硫杂环戊烷,然后再和取代芳香醛缩合得到3种未见文献报道的新化合物。结果总收率在60%以上。结构经IR,MS,1HNMR和元素分析所确证。结论该类化合物合成方法简单。初步的生物活性实验表明,这3种化合物对大肠杆菌、肺炎克雷伯氏菌、草绿色链球菌等有较好的抑杀作用。OBJECTIVE To find a more effective antiseptic, three new 2-(2,-substituted hydrazono)-1,3-dithiacyclopentane derivatives were synthesized under Ultrasound irradiation.METHODS With CS_2, NH_2NH_2·H_2O, BrCH_2CH_2Br and substituted benzaldehydes three new 2-(2,-substituted hydrazono)-1,3-dithiacyclopentane derivatives have been synthesized under Ultrasound irradiation. RESULTS Structures of the prodaucts were confirmed by IR, ~ 1HNMR, MS and elemental analysis. CONCLUSION Preliminary bioactivity test indicates their good antimicrobial activity.

关 键 词：烷类化合物 抗菌活性 杂环 肺炎克雷伯氏菌 硫 ^1HNMR 草绿色链球菌 肼 合成中间体 超声波辐射 超声波法 新化合物 文献报道 元素分析 合成方法 生物活性 大肠杆菌 抑杀作用 杀菌剂 CS2 H2O 环戊烷 总收率 

分 类 号：R734.2[医药卫生—肿瘤] R978.1[医药卫生—临床医学]