云锡矿粉烟尘诱发性肺腺癌形态计量和DNA含量测定研究  

Quantitative analysis of cellular morphometry andDNA vontent measurment of experimental lung adeno-carcinoma

作　　者：黄润[1] 陆建波[1] 王国英[1] 章宗籍[1] 和映藻[1] 黄翠轩[1] 张华献[1] 

机构地区：[1]昆明医学院病理教研室

出　　处：《中华结核和呼吸杂志》1994年第5期297-300,共4页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：采用图像分析仪对云锡矿粉、烟尘诱发性肺腺癌过程中正常支气管粘膜上皮、增生支气管粘膜上皮、癌前病变和肺腺癌（组序１～４）的细胞进行形态计量及ＤＮＡ含量测定。由１６项几何学参数经逐步判别分析选出７项参数，回代判别分类准确率达９５％。ＤＮＡ含量测定１和２组均不出现大于５倍体细胞，大于５倍体细胞在３组为４．Ｏ％，４组为１０．８％，且３组、４组间差异存在显著性（Ｐ＜０．０１）。his article reported the image analysis of normalepithelia of bronchi (groupl i, hyperplasia epithelia(group 2) . atypical hyperplasia epithelia (group 3)and adenocarcinoma (group 4) of the lung in the hamsters induced by tin mine dust and chimney dust inYunnan Tin Min CO. 16 parameters were observedand compared. Each value was tested by stepwise discriminational classification and an accuracy rate of95% was reached. DNA ploidy was investigated. andno case of >5C cell was found in normal and hyperplasia group. Severe atypia had a lower percentage,(4. 00%) and lung adenocarcinoma was characterizedby a high percentage of >5C cell (10. 75 % ) , A signif-icant difference was shown between the pereentage of>5C cell of severe atypia and that of adenocarcinoma.Significantly different (P< 0. 01) .

关 键 词：肺肿瘤 形态计量 细胞形态 粉尘 DNA 

分 类 号：R734.202[医药卫生—肿瘤]