卵巢内胚窦瘤化疗的合理性探讨  

Rational Chemotherapy for Ovarian Endodermal Sinus Tumor

作　　者：王文福[1] 陈淑珍[1] 李玉芝[1] 孙蕊[1] 

机构地区：[1]蚌埠医学院附属医院妇瘤科,蚌埠市233004

出　　处：《中国肿瘤临床》1994年第2期93-95,共3页Chinese Journal of Clinical Oncology

摘　　要：1980～1988年收治22例卵巢内胚窦瘤,按术后残存肿瘤<1cm和>1cm分成两组,两组分别存活期各为46个月和15.5个月(P<0.01).又按术后予以联合化疗和单一化疗分成两组,两组存活期分别为28个月和10个月(P<0.05).术后首先应用腹腔联合化疗,越早越好.DDP和5—Fu联合腹腔化疗较合理,3次后每月1次VAC方案全身化疗效果较佳.少数病例在7～8个疗程后加全腹^(60)Co外照射.早期病例应行腹膜后淋巴清除术.连续测定AFP可作为治疗监护和评价预后.不宜行二次探查术.Twenty two cases of endodermal sinus tumor of the ovary were treated. Patients with residual tumor less than 1cm in diameter or thickness after surgery (group A)and patients with residual tumor greater than 1cm after surgery(group B)were given chemotherapy. The average survivals of group A and B Were 46 months and 15. 5 months respectively (P<0. 01). The average survivals of group C which received multidrug chemotherapy and group D which received single drug chemotherapy were 28 months and 10 months respectively(P<0. 05). Multidrug intraperitoneal chemotherapy with 5-FU and DDP was suggested soon after surgery.and the chemotherapy with VAC regimen monthly was advisable. Retroperitoneal lymphadenectomy can be beneficial. Serial determinations of serum AFP is useful in monitoring treatment result and in evaluation of prognosis. Second look laparotomy is inadvisable.

关 键 词：内胚窦瘤 卵巢肿瘤 药物疗法 

分 类 号：R737.310.5[医药卫生—肿瘤]