非何杰全氏淋巴瘤流式细胞术分析及其临床意义探讨  

Flowcytometric Analysis of Non-Hodgkin's Lymphoma and Its Clinical Significance

作　　者：王伟光[1] 纪树荃[1] 孟如松[2] 单远[3] 

机构地区：[1]空军总医院血液科,北京市100036 [2]空军总医院病理科,北京市100036 [3]解放军总医院

出　　处：《中国肿瘤临床》1994年第6期412-415,共4页Chinese Journal of Clinical Oncology

摘　　要：应用流式细胞术(FCM)对86例非何杰金氏淋巴瘤(NHL)石蜡包埋组织细胞DNA含量进行分析.结果表明,86例 NHL中的28例为异倍体(32.6%),其余为二倍体.高度恶性(HG)及中度恶性(IG)组异倍体发生率明显地高于低度恶性(LG)组(P<0.01).但是,HG、与 IG组间差异不显著(P>0.05).异倍体发生率与分期及患者年龄、性别无关.HG、IG和 LG三者间S期比率差异显著或极显著.S期比率>18%病人 2年存活率显著低于 S期比率≤18%者(P<0.01).Cellular DNA content of paraffin-embedded tumor samples from 86 patients with Non-Hodgkin's lymphoma(NHL)was analyzed using flowcytometry(FCM). The results showed that 28(32. 6%) of 86 NHL were heteroploid tumors,and the remainder were diploid tumors. The incidence of heteroploid in NHL with high grade and intermediate grade malignancy was significantly lower than that with low grade malignancy (P<0. 01),but no significant difference was found between high grade and intermediate grade groups (P<0. 05),but no significant difference was found between high grade and intermediate grade groups(P> 0.05).The incidence of heteroploid was not correlated with stage,age and sex. S-phase fractions were remarkably different among low grade,intermediate grade and high grade groups. Two-year survival rate of patients with S-phase fraction≥1 8% was significantly lower than that of patients with S-phase fraction<18% (P<0. 01).

关 键 词：非何杰金氏 淋巴瘤 流式细胞术 

分 类 号：R733.03[医药卫生—肿瘤]