血小板膜糖蛋白I bα基因多态性与脑梗死关系的研究  

Relationship between gene polymorphism of platelet glycoprotein Ⅰ bα and cerebral infarction

作　　者：高旭光[1] 霍阳[1] 彭莉[1] 滕智平[2] 任正洪[3] 

机构地区：[1]北京大学人民医院神经内科,100044 [2]北京大学人民医院血液科 [3]北京大学医学部公共卫生学院

出　　处：《脑与神经疾病杂志》2005年第3期186-188,共3页Journal of Brain and Nervous Diseases

摘　　要：目的:探讨血小板膜糖蛋白I bα基因HPA2多态性与脑梗死之间的关系。方法:选取按年龄、性别、有无高血压及糖尿病病史相匹配的病例组及对照组各100例,PCR扩增GPI bα基因长为588bp的片段,产物经限制性内切酶Hinl I消化后确定其基因型。结果:在总病例组、大动脉粥样硬化型脑梗死组及小动脉闭塞型脑梗死组(TOAST分型)与相应对照组之间GP I bαHPA2基因型频率的分布差异无显著性;大动脉粥样硬化型中杂合突变型比例(16.1%) 要高于小动脉闭塞型中杂合突变型比例(10.1%),但差异无显著意义。结论:GP I bαHPA2基因杂合突变型可能并非脑梗死的危险因素。Objection: To study the relationship between gene polymorphism ofplatelet glycoprotein Ⅰ bα and cerebral infarction. Methods:100 patients and 100 controls matched for age (within 3 years), race, sex, history of hypertension and diabetes mellitus(yes or no) were enrolled in the study. Genotyping for GP Ⅰ bαa polymorphism was performed by pol-ymerase chain reaction (PCR) amplification and restriction enzyme analysis. Results: There were no statistically significant differences of the GP Ⅰ1 bα HPA2 genotype between Large-vessel subtype group, Small-vessel subtype group, both Large-and Small-vessel group (TOAST criteria) and corresponding controls. The heterozygote genotype of GP Ⅰbα HPA2 was more frequent in Large-vessel subtype group( 16. 1% )than that in Small-vessel subtype group( 10. 1% ), but the difference was not statistically significant. Conclusion: The polymorphism of GP Ⅰ bα HPA2 genotype might not be genetic risk factor of cerebral infarction.

关 键 词：脑梗死 血小板膜糖蛋白IBΑ 多态性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]