丙型肝炎病毒感染者姐妹染色单体互换率的观察  

A STUOY ON THE SISTER CHROMATID EXCHANGE IN LYMPHOCYTES OF HCV CARRIERS

作　　者：李明烈[1] 程俊[1] 陈良年 毛远萍 George E 

机构地区：[1]上海市肿瘤研究所 [2]加拿大ＹＥＳ生物技术公司 [3]上海吴泾化工总厂

出　　处：《中华传染病杂志》1994年第2期92-94,共3页Chinese Journal of Infectious Diseases

摘　　要：作者选择丙型肝炎病毒（ＨＣＶ）携带者和正常健康者各２０例作外周血淋巴细胞的姐妹染色单体互换率（ＳＣＥ）的比较分析，结果显示两组供血者的ＳＣＥ值分别为６．７５７±０．１０２和４．９６７±０．０７６。差异呈十分显著性（Ｐ＜０．００５）。ＨＣＶ组中期分裂相的Ｍ１，Ｍ２和Ｍ３三个细胞分裂周期的百分率分别为４８．１±４．２；３５．３±５．１和１６．６±４．８。细胞分裂周期呈明显延长趋势。ＨＣＶ携带者的染色体不稳定性提示ＨＣＶ与原发性肝细胞癌（ＰＨＣ）的发生可能具有重要相关性。The sister chromatid exchange(SCE)in lymphocytes was studied in 20 hepatitis Cvirus carriers(HCVC)and 20 normal subjects(NSas controls.The results showed thatthe SCE frequencies were found to be 6.757 ± 0.102 and 4.967 ± 0.076 in HCVC andNS respectively with difference being highly significant(P<0.0 05).The percentages of3 mitosis cycles(M1,M2,M3) in the two groups were 48.1 ±4.2;35.3 ± 5.1:16.6 ± 4.8and 34.4±5.5;39.3±5.2;26.3±4.1 respectively,showing that the difference is signi-ficant in M1 and M3(P<0.01).According to our preliminary study,it is suggestedthat there is significant chromosome instability in HCVC,and HCV may probably beassociated with PHC.

关 键 词：丙型肝炎病毒 肝细胞癌 肝肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]