伤寒沙门氏菌耐药性及其耐药质粒的监测  

SURVEILLANCE OF THE ANTIBIOTIC RESISTANCE AND R PLASMID OF SALMONELLA TYPHI

作　　者：黄瑞[1] 穆荣谱 

机构地区：[1]苏州医学院生物技术研究所

出　　处：《中华传染病杂志》1994年第4期202-205,共4页Chinese Journal of Infectious Diseases

基　　金：中国核工业总公司;江苏省卫生厅基金

摘　　要：对１９８７～１９９２年从苏州地区分离的５９１株伤寒沙门氏菌的耐药监测发现，１９８７～１９８８年耐药菌株流行后的４年间，伤寒杆菌对大多数抗生素恢复了敏感性。对耐药菌株进行的质粒检测、结合转移、转化及消除试验证明：伤寒杆菌的多重耐药性系一分子量为９８．６Ｍｄａｌ的质粒所介导。对伤寒杆菌耐药性的持续监测，研究阐明其演变及消长规律，为耐药伤寒防治及最终建立对Ｒ质粒传递的消除和阻断方法有重要意义。9l strains of Salmonella typhi isolated in Suzhou area during l987～1992 werestudied .The strains isolated in l987 and l988 were multiresistant to 8 tol0 antibiotics,but there after most of the strains restored gradully their durg sensitivity resistant andbecame to only l to 2 antibiotics,especially to Stretomycin. Plasmid electrophoresis,conjugation,transformatoin and elimination study showed that the multiresistant S.typhi was mediated by a large plasmid of 98.6Mdal,(although the resistant types ofstrains were different,from 2 to l0.Surveillance of the antibiotic resistance and Rplasmid of bacteria will be helpful to explore the ways of control the spread of Rplasmid and antibiotic resistant strains.

关 键 词：伤寒沙门氏菌 药敏试验 质粒检测 抗药性 

分 类 号：R378.23[医药卫生—病原生物学]