固载脯氨酸类手性催化剂的制备及在不对称Aldol反应中的催化作用  

Preparation of Supported Proline-derived Chiral Catalysts and Their Catalytic Application in Asymmetric Aldol Reactions

作　　者：沈宗旋[1] 焦崇峻[1] 丁一[1] 马济美[1] 顾佳[1] 张雅文[1] 

机构地区：[1]苏州大学化学化工学院

出　　处：《化学研究》2005年第2期22-25,共4页Chemical Research

基　　金：江苏省有机合成重点实验室资助课题(JSK015)

摘　　要：制备了两种二氧化硅-甲基纤维素-脯氨酸类手性小分子复合催化剂,证明了它们可以在室温下催化不对称Aldol反应.所得产物产率较高,ee值最高能达到86.8%.这些催化剂比较稳定,并具有一定的重复使用的性能.Two new silica-supported methylcellulose-chiral small organic molecule complexes have been prepared and found to be effective catalysts for asymmetric aldol reaction of acetone with benzaldehydes at room temperature.The desired aldol adducts were obtained in good yield with ee up to 86.8%. These catalysts were very stable and could be recycled for several times.

关 键 词：ALDOL反应 不对称 手性催化剂 催化作用 制备 酸类 固载 氨 甲基纤维素 复合催化剂 二氧化硅 小分子 

分 类 号：O623.521[理学—有机化学] O621.34[理学—化学]