急性白血病细胞遗传学研究及其临床意义  

CYTOGENETIC STUDY OF CHILD-HOOD ACUTE LEUKEMIA AND ITS CLINI-CAL SIGNIFICANCE

作　　者：范伯丽[1] 郭淑芬[1] 徐淑芝[1] 汤永民[1] 沈红强[1] 

机构地区：[1]浙江医科大学附属儿童医院

出　　处：《中华儿科杂志》1994年第6期331-333,共3页Chinese Journal of Pediatrics

基　　金：浙江省自然科学基金

摘　　要：应用高分辨同步化染色体制备技术等对７０例小儿急性白血病进行细胞遗传学研究，５８例（初诊及复发）检出异常核型（８１％），其中急性淋巴细胞白血病异常核型检出率为７８％，急性非淋巴细胞白血病异常核型捡出率为８６％。对３１例患儿的核型与临床关系进行观察，发现小儿急性白血病染色体结构异常可视为预后不佳的标志，而正常二倍体核型及超二倍体核型的急性白血病（尤其是超过５０条的急性淋巴细胞白血病）则预后较好。还对８例小儿急性白血病核型进行动态观察以及对１２例持续完全缓解者进行随访，认为细胞遗传学研究对小儿急性白血病的诊断分型、预后判断及指导治疗具有重要意义。AbstractUsing high -resolution chromosonie preparations ,we successfully perforrned cytogenetic study on child-hood acute leukernia. Abnormal karyotypes were foundin 47 out of 58 patients(81%). Abnormal chromoso-mal patterns were revealed in 77.78% of patients withALL and 85. 7% of patients with ANLL. The correla-tion between karyotype and short- term therapeuticresults was investigated in 31 patients with AL and se-rial observations in the course of disease were conductedon bone marrow karyotypes in 8 patients we found thatthose with structuriil abnormality had poor prokrnosisand those with nornial and hypertliploitly (over 50)karyotypes sliowed fEixorable manifestations and therapeutic results. The cyiogenetie analysis of 12 patientsin continuous complete remission was followed up. Weconclude that cyiogenetic study on leukemic cells is ofgreat value in diagnosis. lirediction of prognosis andguidance for treatnient in patients with acute leukemia

关 键 词：白血病 核型 细胞遗传学 儿童 

分 类 号：R733.710.3[医药卫生—肿瘤]