喉癌患者染色体对致突变剂诱发畸变的敏感性研究  

Pingyangmycin-induced Chromosome Damage in Lymphocytes of Laryngeal Cancer Patients

作　　者：李安太[1] 王天锋[1] 杨瑞芳[1] 栾信庸[1] 王明毅[1] 

机构地区：[1]山东医科大学附属医院耳鼻咽喉科,山东医科大学附属医院遗传室

出　　处：《中华耳鼻咽喉科杂志》1994年第6期333-335,共3页Chinese Journal of Otorhinolaryngology

基　　金：卫生部科研基金

摘　　要：采用平阳霉素作为诱变剂，对２８例喉癌患者和２３例正常人做外周血淋巴细胞染色体对诱变剂敏感性研究，结果显示喉癌患者的染色体总畸变率、每细胞染色单体断裂率（ｂ／ｃ值）和细胞畸变率分别为１．９８％±０．０５％，０．５７％±０．３５％和４２．８％±１２％。正常人则分别为０．９４％±０．０４％，０．２８％±０．１２％和２７％±１２％。经统计学处理，喉癌患者组与正常人组的差异有高度显著性。并结合实验结果探讨了染色体对致突变剂的敏感性与患喉癌风险的关系。Lymphoeytes from28 untreated laryngeal cancer patients and23 healthy controls were cultured in vitro and exposured to pingyangmycin(bleomycin A5),a clastogen,The lymphocytes were arrested in metaphase and analyzed.The total chromosome aberration rate,mean chromatid break rate per cell and cell aberration rate were 1.98%±0.05%,0.57%±0. 35%, and 42.8%±12%respective-ly for laryngeal cancer patients. However,for healthy controls these values were 0. 94%±0. 04%,0. 28%±0. 12%,and 27%±12%respectively. Statistical analysis showed there are significant differ-ences between the two groups, The data indicate that under our experimental conditions chromatid break rate 0. 40 can be considered to be a borderline value,0. 80 hypersensitive value. For any individu-l, if the chromatid break rate is 0. 40 or more, one should be ranked as having cancer risk.If 0.80 or more,then, highly cancer risk.

关 键 词：喉肿瘤 鳞状细胞癌 染色体 致突剂 畸变 

分 类 号：R739.650.2[医药卫生—肿瘤]