卵巢癌患者免疫抑制因子的研究  

Study on the immunologic suppressor factors insera of patients with ovarian cancer

作　　者：李广太[1] 张士伟[1] 钟述猷[1] 刘政[1] 

机构地区：[1]天津医学院附属医院妇产科

出　　处：《中华妇产科杂志》1994年第7期392-394,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：用淋巴细胞增殖和增殖抑制方法测定３４例卵巢癌患者血清免疫抑制因子，发现术前卵巢癌患者血清可明显抑制植物血凝素（ＰＨＡ）诱导的淋巴细胞增殖反应，且这种抑制呈剂量依赖关系，当血清被稀释到１：４０００时仍有明显抑制活性。同时与子宫颈癌、子宫内膜癌、胃癌和肺癌患者血清抑制活性进行比较。结果表明，术前卵巢癌患者血清对卵巢癌患者淋巴细胞的抑制强于胃癌或肺癌患者血清。提示：免疫抑制因子在卵巢癌发生及发展中起着重要作用。he suppressive activity of immunologicsuppressor factors (ISF) in the sera of 34 patients withovarian cancer was investigated by using thelymphocyte proliferation and inhibition test. It wasfound that the sera of the preoperative patients couldsignificantly suppress PHA-induced lymphocyte re-sponse, and that the suppression was dose-dependent.When the sera were diluted to 1 : 4 000, the sup-pressive activity could still be demonstrated. We alsoobserved the suppressive activities in the sera of pa-tients with eervical cancer, endometrial cancer, gastriccancer and lung cancer, and compared them withovarian cancer patients. The observation showed thatthe suppressive activity in the sera of preoperativeovarian cancer patients was higher than that in thesera of gastric cancer or lung cancer patients. These re-sults suggested that ISF played an important role inthe development of ovarian cancer.

关 键 词：免疫抑制因子 卵巢肿瘤 

分 类 号：R737.310.3[医药卫生—肿瘤]