I期卵巢上皮性癌的预后因素  

Prognostic factors in patients with stage Iepithelial ovarian caucer

作　　者：温宏武[1] 刘书文[1] 

机构地区：[1]北京医科大学第一医院妇产科

出　　处：《中华妇产科杂志》1994年第4期235-237,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：对我院１９６２年至１９８９年收治的６７例Ｉ期卵巢上皮性癌患者进行回顾性分析。按收治年代将其分为三组。结果：三组除采用的化学疗法（化疗）的方法不同外，其它治疗及患者的临床病理特点比较，差异无显著意义。６０年代（第一组）、７０年代（第二组）、８０年代（第三组）治疗的愚者预后随时间逐步改善，其５年生存率分别为４６％、８２％和９７％。第一组与第二组５年生存率比较，差异有非常显著意义（Ｐ＜０．００１）；第二组与第三组比较，差异有显著意义（Ｐ＜０．０５）。多因素分析显示，化疗及临床分期是影响预后的重要因素（Ｐ均＜０．０１），其次是病理分级（Ｐ＜０．０５）。多疗程联合化疗、Ｉａ期患者及肿瘤分化Ｉ、ＩＩ级患者预后好。本研究还就Ｉ期卵巢上皮性癌的化疗、手术准确分期及保留生育功能进行了讨论。From 1962 to 1989,67 patients with stage Iepithelial ovarian cancer were treated in our hospital.They were divided into three groups according to thetime period of treatment.Thirteen patients treated inthe 1960s were in group 1,23 in the 1970s in group2,and 31 in 1980s in group 3.There were no other signi-ficant differenees other than the adjuvantchemotherapy in the three groups.In this study, the5-year survlval rate was 46% in group 1(1962～190),82% in group 2(1970～1979),and 97% ingroup 3( 1980～1989).The prognosis was improvedsignificantly from 1960s to 1970s (P< 0.005),as well asfrom 1970s to 1980s(P<0.05).Multivariate analysisindicated adjuvant chemotherapy(P<0.01),stage(P<0.01),and histological grade(P<0.05)as havingindependent prognosticeffects.Patients with morethan 4 courses of combination chemotherapy,stage la,grade I and grade II had a better survival rate.Thechemotherapy,complete surgical staging and preserva-tion of fertility in surgical treatment of stage Iepithelial ovarian cancer were aslo discussed.

关 键 词：卵巢肿瘤 肿瘤分期 预后 上皮癌 

分 类 号：R737.310.7[医药卫生—肿瘤]