己酸孕酮治疗子宫内膜癌前期病变的生殖激素水平变化  

Change of reproductive hormones levels in thetreannent of endometrial precancerous lesionwith hydroxyprogesterone caproates

作　　者：杨丹[1] 朱人烈[1] 

机构地区：[1]上海医科大学妇产科医院

出　　处：《中华妇产科杂志》1994年第4期205-206,共2页Chinese Journal of Obstetrics and Gynecology

摘　　要：孕激素类药物治疗子宫内膜癌已有３０多年历史，具有一定疗效，但孕激素类药物的作用环节尚不明确。本研究用己酸孕酮治疗１４例子宫内膜癌前期病变患者，观察用药前后生殖激素水平的变化。结果表明，促黄体生成激素（ＬＨ）、促卵泡激素（ＦＳＨ）与促黄体生成激素比值（ＬＨ／ＦＳＨ），均比用药前明显下降（Ｐ＜０．０５，Ｐ＜０．０１）。提示：孕激素类药物的作用是多环节的，其中作用于垂体部位，选择性的影响ＬＨ分泌和ＬＨ／ＦＳＨ是环节之一。he efficacy of progesterone in treating patientswith endometrial carcinoma is well known. The mech-anism,however,has not been understod yet.In thispaper,14 cases of precancerous lesion of endometriumwere treated with hydroxyprogesterone caproates andaseries of hormone detennination was analysdbeforeand after treatment.Results Showed that LH andLH / FSH were dramatically decreased.(LH P < 0.05,LH / FsH P < 0.01).It is suggested that the mecha-nism of progesterone is multiphase,one of them is in-fluenee on pituitary and selective interference of LHand LH/FSH.

关 键 词：子宫内膜癌 癌前病变 己酸孕酮 

分 类 号：R737.330.5[医药卫生—肿瘤]