恶性滋养细胞肿瘤细胞中胎盘激素的测定  

A study on the expression of human chorionicgonadotropin,human placental lactogen andpregnancy-specific 1-glycoprotein in malig-nant trophoblastic neoplasms

作　　者：熊永炎[1] 曾俊[1] 唐志佼[1] 邢寿富[1] 

机构地区：[1]湖北医科大学病理学教研室

出　　处：《中华妇产科杂志》1994年第10期610-613,共4页Chinese Journal of Obstetrics and Gynecology

摘　　要：应用免疫组化方法，采用抗绒毛膜促性腺激素（ｈＣＧ）、胎盘泌乳素（ｈＰＬ）、妊娠特异性ｐ１糖蛋白（ＳＰ１）抗体，检测９１份恶性滋养细胞肿瘤瘤细胞中胎盘激素的含量，其中侵蚀性葡萄胎２９份、转移性侵蚀性葡萄胎１２份，绒毛膜癌２９份、转移性绒毛膜癌２１份。结果：侵蚀性葡萄胎肿瘤细胞中ｈＣＧ的含量较绒毛膜癌明显减少（Ｐ＜０．００５），ｈＰＬ和ＳＰ，的含量较绒毛膜癌明显增多（Ｐ＜０．００５）；转移性侵蚀性葡萄胎肿瘤细胞中ｈＰＬ、ＳＰ＿１的含量较原发瘤为低（Ｐ＜０．０２５），转移性绒毛膜癌的ｈＣＧ及ｈＰＬ含量较原发瘤增多（Ｐ＜０．１，Ｐ＜０．０５）。提示：ｈＣＧ、ｈＰＬ和ＳＰ＿１在恶性滋养细胞肿瘤瘤细胞中含量的测定，对该瘤的诊断和分型有参考价值。he expression of placental hormones in 91 malig-nant trophoblastic neoplasms was studied immunohis-tochemically using a panel of antibodies against hCG,human placental lactogen (hPL)and pregnancy-specif-ic 1-glycoprotem(SP).The results indicated that theexpression of hCG in invasive moles was weaker thanthat in choriocarcinoma,but the expression of hPL andSP_1 was stronger than those in choriOcarcinoma,Theexpression of hPL and SP_1 in the metastatic tumors ofinvasive moles was weaker than the expression at in theprimary tumors,but the secretory capacity of hCG inmetastatic choriocarcinomas was stronge than that in theprimary neoplasms. In this study,the qualities of ex-pression of the placental hormones in invasive moles andchoriocarcinomas corresponded to the degree of tumormalignancy,the biological behaviour and the grading oftrophoblastic cell differentiation. We belive that the de-tection of hCG, hPL and SP_1,in malignant trophoblas-tic neoplasms was of value for establishing tumor diag-nosis and typing and for judgement on prognosis.

关 键 词：胎盘激素类 滋养层肿瘤 免疫组织化学 

分 类 号：R737.330.3[医药卫生—肿瘤]